Neuroscience

Neuroscience

eLife reviews research including brain function, neuronal circuits, synapses, sensory processing and motor pattern generation. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience

    Neural Connectome of the Ctenophore Statocyst

    Kei Jokura, Sanja Jasek ... Gáspár Jékely
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Toward Robust Neuroanatomical Normative Models: Influence of Sample Size and Covariates Distributions

    Camille Elleaume, Bruno Hebling Vieira ... the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Identifying regulators of associative learning using a protein-labelling approach in Caenorhabditis elegans

    Aelon Rahmani, Anna McMillen ... Yee Lian Chew
    An innovative and scalable proximity labelling method profiled proteins present in the Caenorhabditis elegans brain during learning, identifying known regulators as well as novel biological pathways.
    1. Neuroscience

    Executive resources shape the impact of language predictability across the adult lifespan

    Merle Marie Schuckart, Sandra Martin ... Jonas Obleser
    Analyses of self-paced reading times reveal that linguistic prediction deteriorates under limited executive resources, with this resource sensitivity becoming markedly more pronounced with advancing age.
    1. Neuroscience

    Spatially Periodic Computation in the Entorhinal-Hippocampal Circuit During Navigation

    Bo Zhang, Xin Guan ... Jia Liu
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

    Kelsey M Nemec, Genevieve Uy ... F Chris Bennett
    A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
    1. Neuroscience

    TRPV3 channel activity helps cortical neurons stay active during fever

    Yiming Shen, Richárd Fiáth ... Michelle W Antoine
    Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C during fever.
    1. Neuroscience

    Inhibitory circuits control leg movements during Drosophila grooming

    Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
    Anatomical and behavioral characterization of inhibitory neurons in the Drosophila ventral nerve cord shows their critical, diverse roles in limb coordination.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Developmentally-based directed differentiation from cortical progenitors sets a foundation for in vitro mechanistic and therapeutic disease modeling, and toward regenerative neuronal repopulation and circuit repair.
    1. Neuroscience

    Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output

    John J Marshall, Jian Xu ... Anis Contractor
    Bidirectional modulation of the activity of the synaptic protein mGluR5 alters spontaneous mouse motor behavior and produces correlated changes in co-activity patterns among direct pathway neurons in the dorsal striatum.

Senior editors

  1. Yanchao Bi
    Peking University, China
  2. Merritt Maduke
    Stanford University School of Medicine, United States
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors