A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper.
Movie alignment software uses a 3D spline model to capture beam-induced motion in cryo-electron microscopy movie frames, correct local sample distortions, and improve two-dimensional template matching signal-to-noise ratios in the corrected images.
Resolving the mechanism of RXR ligand-dependent NR4A-RXR nuclear receptor heterodimer activation requires a diverse ligand set that includes heterodimer-selective agonists.
The JAX Animal Behavior System integrates standardized hardware, machine learning methods, and annotated datasets to enable reproducible behavioral phenotyping and genetic analysis across diverse mouse strains.
Preethi Somasundaram, Madeline M Farley ... Trent A Watkins
A secondary stress signaling pathway in the response to optic axon injury is an unexpectedly strong contributor to both neurodegeneration and axon regenerative potential.
Francesca S Wong, Simon Killcross ... Nathan M Holmes
The basolateral amygdala complex and perirhinal cortex function like the focal and peripheral states of attention described by classic associative learning theories.
Mixture discrimination training induces durable, transferable olfactory learning, highlighting mixture configural odor quality as a distinct attribute supported by different plasticity mechanisms than chirality or concentration and offering a promising leverage point for olfactory rehabilitation.
Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
Structures of the chromatin remodelling enzyme Chd1 during ongoing reactions reveal a reaction pathway tuned to generate nucleosome spacing similar to that observed in cells.
Establishment of AA263 analogs with improved potential for correcting pathologic disruptions of endoplasmic reticulum proteostasis implicated in the onset and pathogenesis of etiologically diverse diseases.
