A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
Peptidisc-based thermal proteome profiling enables detergent-free mapping of membrane protein–ligand interactions, advancing the discovery of druggable targets in membrane-mimetic environments.
Aalimah Akinosho, Joseph Alexander ... Andres Gabriel Vidal-Gadea
Independent replication confirms that avoidance of pathogenic PA14 learned by Caenorhabditis elegans persists through the F2 generation using standardized sodium azide immobilization choice assays, clarifying prior reproducibility concerns.
Computational modeling of the memory modification process reveals biased internal states in an Alzheimer’s disease mouse model, providing a new approach for early cognitive assessment and diagnosis.
Daria M Odermatt, Frank Chidawanyika ... Meredith C Schuman
'Push-pull' agro-ecosystems appear to protect maize against the fall armyworm, but volatiles from Desmodium intercrops are not sufficient to reliably repel this herbivore, indicating that additional mechanisms contribute to protection.
Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
Cryo-electron tomography reveals plant photosynthetic membranes with single-complex precision, supporting a simple two-domain model of membrane organization.
Bruno Cuevas Zuviría, Franka Detemple ... Betül Kaçar
Structural reconstruction of thousands of ancient nitrogenases through Earth’s history uncovers architectural constraints that shaped their evolution under global environmental transitions.
Jessica Mella, Regan F Volk ... Abigail Buchwalter
The inner nuclear membrane protein emerin readily traffics through the secretory pathway via its hydrophobic transmembrane domain when tagged with C-terminal GFP.
Motile Enterobacteriaceae override chemorepulsion from the microbiota metabolite indole in favor of nutrient attraction, challenging the idea that indole taxis protects the host against intestinal infection.
Humans can appropriately use relationships among pieces of sensory evidence (pairwise correlations) to inform decisions, rather than relying only on the physical features of individual evidence samples.
