Substrate recognition by a receptor protein tyrosine phosphatase is mediated by binding to its pseudophosphatase domain via a short helix that is >100 amino acids distant from the target phosphosite, uncovering principles of phosphatase substrate recognition and potential scaffolding functions.
Tanja Fuchsberger, Claudia Clopath ... Ole Paulsen
Neuronal reactivation during dopamine modulation induces input-specific LTP at previously primed hippocampal synapses, suggesting a possible solution to the credit assignment problem and a mechanism for memory linking.
Dylan J Meyer, Carlos Manlio Díaz-García ... Gary Yellen
Neuronal glycolysis to restore energy consumed by ion movements is activated by engagement of the Na+/K+ pump, either directly by Na+ influx or indirectly, when Ca2+ influx is converted to Na+ accumulation by Na+/Ca2+ exchange.
Edmundo G Vides, Ayan Adhikari ... Suzanne R Pfeffer
Parkinson’s disease-associated LRRK2 kinase is recruited to membranes by its Rab GTPase substrates, and LRRK2 is both retained on membranes and further activated there by cooperative interaction with the phosphorylated Rab proteins that it generates.
As Caenorhabditis elegans adult hermaphrodite germ cells leave the stem cell niche, they associate with a pair of somatic gonad cells that were thought to be symmetrical, but that actually take on dramatically different positions in the organ.
By identifying cohesin's DNA entry gate(s) and through understanding the corresponding topology between the two the mechanism behind cohesin's activity is slowly deciphered and will aid in understanding how the SMC family at large functions.