Browse our Research Advances

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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism

    Francisco Prieto-Ruiz, Elisa Gómez-Gil ... José Cansado
    A highly sophisticated and adaptive interplay between modulation of myosin II function by light chain phosphorylation and environmentally controlled formin availability, is critical for a successful cytokinesis during respiratory carbohydrate metabolism in the fission yeast Schizosaccharomyces pombe.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins

    Richard Benton, Nathaniel J Himmel
    A new screening strategy for divergent homologs of insect odorant and gustatory receptors, based upon predicted three-dimensional structural similarity, unexpectedly identifies candidates in humans.
    1. Neuroscience

    Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

    Sahab Arinrad, Constanze Depp ... Klaus-Armin Nave
    Loss of myelin integrity in the mouse forebrain perturbs executive functions, assessed by tests requiring normal motor performance.
    1. Structural Biology and Molecular Biophysics

    Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

    Tamar Skaist Mehlman, Justin T Biel ... Daniel A Keedy
    Many small-molecule fragments bind differently to the allosteric protein PTP1B in room-temperature instead of cryogenic crystal structures, which may be relevant for structure-based drug design.
    1. Genetics and Genomics

    Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency

    Bryn D Webb, Sara M Nowinski ... Sander M Houten
    Biallelic variants in MCAT are associated with combined oxidative phosphorylation deficiency in humans and a clinical presentation that includes hypotonia, developmental delay, failure to thrive, and nystagmus.
    1. Ecology
    2. Evolutionary Biology

    Community diversity is associated with intra-species genetic diversity and gene loss in the human gut microbiome

    Naïma Madi, Daisy Chen ... Nandita R Garud
    Longstanding eco-evolutionary theories are tested using shotgun metagenomic data from the human gut microbiome, showing links between community diversity and the evolutionary trajectory of a focal species within the community.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation

    Marco Caligaris, Raffaele Nicastro ... Claudio De Virgilio
    Discovery of new Snf1/AMPK targets in the TORC1 pathway highlights the complex, multilayered crosstalk between major signaling pathways in the regulation of nutrient deprivation sensing.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

    Serkan Sayin, Brittany Rosener ... Amir Mitchell
    Mutations conferring resistance to Escherichia coli against the chemotherapy drug gemcitabine can have opposite effects on bacterial drug degradation and therefore can increase or decrease the chemotherapy load on neighboring cancer cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

    Hidehiko Okuma, Jeffrey M Hord ... Kevin P Campbell
    N-terminal domain of dystroglycan enables like-acetylglucosaminyl transferase to elongate matriglycan on α-dystroglycan and prevent skeletal muscle pathophysiology.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

    Janice M Reimer, Morgan E DeSantis ... Andres E Leschziner
    Structures of human cytoplasmic dynein-1 bound to its regulator LIS1 reveal the interfaces involved in forming the complex and provide a context for disease-linked mutations.