Browse our Research Advances

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    1. Cell Biology

    NECAPs are negative regulators of the AP2 clathrin adaptor complex

    Gwendolyn M Beacham et al.
    Endocytosis is regulated by a protein family that recycles the AP2 clathrin adaptor by restoring the inactive form of complex.
    1. Neuroscience

    Interactions between stimulus and response types are more strongly represented in the entorhinal cortex than in its upstream regions in rats

    Eun-Hye Park et al.
    Goal-directed interaction with objects and spatial navigation are subserved by the perirhinal-lateral entorhinal networks and the postrhinal-medial entorhinal networks, respectively, with action-based functional differentiation more strongly represented in the entorhinal cortex than its upstream.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

    Megan C Kopp et al.
    Quantitative FRET UPR induction assay is used to measure IRE1 and BIP association and dissociation by a variety of ER misfolded proteins and by an important BiP substrate-binding domain mutant, significantly enhancing the evidence for the allosteric UPR induction model.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

    Han Han et al.
    A 3.2 Å resolution structure of Vps4 provides a detailed model for protein substrate binding and translocation by AAA ATPases.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The structure of the COPI coat determined within the cell

    Yury S Bykov et al.
    Cryo-electron tomography of COPI vesicles in the Golgi reveals coat structure, disassembly dynamics, cargo binding, and morphological variability.
    1. Developmental Biology and Stem Cells

    Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

    Jason Karch et al.
    Molecular pathways controlling autophagic cell death are regulated at the level of the lysosome through the activity of the pro-death Bcl-2 family member Bax/Bak.
    1. Biochemistry and Chemical Biology

    Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

    Martin Steger et al.
    Parkinson's kinase LRRK2 phosphorylates a distinct subset of Rabs, and LRRK2-dependent phosphorylation links LRKK2 to ciliogenesis.
    1. Neuroscience

    Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors

    Brooks G Robinson et al.
    Desensitization of the D2 autoreceptor is reduced following in vivo cocaine exposure due to plasticity in the D2S and not the D2L splice variant.
    1. Neuroscience

    Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics

    Stephan Gerhard et al.
    The connectivity structure of a nociceptive circuit is precisely maintained over Drosophila larval development through cell type-specific increases in synaptic contacts as measured from electron microscopy reconstructions, while individual neurons grow five-fold in size and number of synapses.
    1. Neuroscience

    Small conductance Ca2+-activated K+ channels induce the firing pause periods during the activation of Drosophila nociceptive neurons

    Koun Onodera et al.
    Drosophila nociceptive neurons convert high-intensity stimuli into characteristic fluctuations of firing rates, quiescent periods of which are regulated by hyperpolarization through small conductance Ca2+-activated K+ channels.