Browse our Research Advances

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    1. Cell Biology
    2. Developmental Biology

    Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

    Maia Kinnebrew et al.
    The patched hedgehog receptor inhibits the transmembrane transducer smoothened by reducing the accessibility of cholesterol locally at the membrane of the primary cilium.
    1. Neuroscience

    Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats

    Kristina M Wright et al.
    Ventrolateral periaqueductal gray neurons signal fear output through patterned inhibition of neural activity.
    1. Neuroscience

    Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition

    Ambra Masuzzo et al.
    The universal bacteria cell wall component peptidoglycan impacts the egg-laying behavior of infected Drosophila females by directly modulating the activity of few brain octopaminergic neurons.
    1. Neuroscience

    Robust olfactory responses in the absence of odorant binding proteins

    Shuke Xiao et al.
    Although odorant binding proteins are widely believed to be required for transport of odorants to receptors, six types of sensilla of Drosophila respond robustly in their absence to many odor stimuli.
    1. Ecology

    Group-specific archaeological signatures of stone tool use in wild macaques

    Lydia V Luncz et al.
    Tool behaviour of long-tailed macaques leaves archaeological signatures that differ between populations despite similar ecological conditions, highlighting the potential for diversity in material culture.
    1. Cancer Biology
    2. Developmental Biology

    Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

    Sara Genovese et al.
    About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Protein engineering expands the effector recognition profile of a rice NLR immune receptor

    Juan Carlos De la Concepcion et al.
    Structure-led protein engineering can expand the effector recognition profile of plant intracellular NLR immune receptors, providing a proof-of-principle for the development of novel disease resistance mechanisms in plants.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

    Edward A Partlow et al.
    Cryo-EM reveals how a protein called NECAP inactivates the AP2 clathrin adaptor complex through concerted engagement of two domains which confer specificity for membrane-activated and phosphorylated AP2.
    1. Neuroscience

    TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

    Bin Wu et al.
    Purkinje cells feature molecular heterogeneity that introduces differentiation in physiological properties between zebrin-identified cerebellar modules and thereby underlies the differential control on sensorimotor integration.
    1. Neuroscience

    In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation

    Morgane Roche et al.
    Brain temperature and oxygenation vary according to the imaging conditions during two-photon microscopy.