Figure 1—figure supplement 1. | Human kinetochores are swivel joints that mediate microtubule attachments

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Human kinetochores are swivel joints that mediate microtubule attachments

Figure 1—figure supplement 1.

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University of Warwick, United Kingdom
Figure 1—figure supplement 1.
Download figureOpen in new tabFigure 1—figure supplement 1. Inter- and intra-kinetochore distances during directed chromosome motion.

(A) Distributions of inter-kinetochore distance, d, for kinetochores expressing no (blue; n = 155,100), low (gold; n = 155,015) and high levels (green; n = 154,626) of Ndc80-tagRFP. Values given are medians ± standard error. (B) Autocorrelation in kinetochore x-displacement between consecutive time points for kinetochores expressing no (blue), low (gold) and high levels (green) of Ndc80-tagRFP. A and B demonstrate no significant perturbation to kinetochore dynamics when expressing exogenous Ndc80-tagRFP. (C) Distributions of Δ 2D for kinetochores moving poleward (P; gold; n = 335) or away-from-the-pole (AP; blue; n = 362), demonstrating no significant difference (p = 0.589). Values given are medians ± standard error.

DOI: http://dx.doi.org/10.7554/eLife.16159.004