Figure 2—figure supplement 4. | TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

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TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

Figure 2—figure supplement 4.

Affiliation details

Cold Spring Harbor Laboratory, United States; Stony Brook University, United States; Huntington Hospital, Northwell Health, United States; University of Southern California, United States; Cancer Research UK – Cambridge Institute, University of Cambridge, United Kingdom
Figure 2—figure supplement 4.
Download figureOpen in new tabFigure 2—figure supplement 4. Differential expression of HDR genes in multiple tumor-derived cell lines at protein level.

(A) Expression of BRCA2, WRN and RDM1 in multiple cancer-derived cell lines characterized by different CD44 CD24 immune types. α-Tubulin is used as a loading control. (B) The charts depict the quantification of relative amounts of BRCA2, WRN and RDM1. Levels of intensity of each band were quantified using imajeJ32 software and are represented as a ratio to α-tubulin. Each bar represents the mean ± SD from two independent experiments.

DOI: http://dx.doi.org/10.7554/eLife.21615.014