A rare mutation that causes a Parkinson’s disease-like disorder in young children interferes with dopamine transporters in the brain, suggesting that treatments targeting the transporters may be beneficial.
Personalised models of cognitive decline offer novel insights into the multiscale alterations in the elderly and diseased brain, with important implications for identifying future treatment targets.
Findings suggest measuring the number of mutations that lead to antibiotic resistance in bacteria is crucial for determining how likely antibiotics are to fail, and should be used to inform new treatment strategies aimed at preventing resistance evolution.
Researchers have described a new approach to analysing the forces at play behind diseased heart vessels, which could help cardiologists predict heart attacks in patients.
A new approach to preventing cancer spread that uses a combination of low-dose, metastasis-inhibiting drugs shows promise in mouse studies and may help prevent drug resistance or relapse.
Researchers have constructed a map of metabolic changes that occur across multiple tissues after a heart attack in the hope of finding targets for better treatments.
People with stroke without atrial fibrillation have the same heart scar tissue as those with atrial fibrillation but may be lacking the triggers that cause heart rhythm disorders.
Researchers have shown that examining both protein changes and the transcription of genes in kidneys provides a more complete picture of the aging process in these organs.
