A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.
Felipe Mora-Bermúdez, Farhath Badsha ... Wieland B Huttner
Neural progenitors in humans and chimpanzee organoids show remarkably similar cellular and molecular parameters, but metaphase is longer during human mitosis.
Sam Vickery, William D Hopkins ... Felix Hoffstaedter
Openly available structural imaging processing pipeline for chimpanzees including registration templates and macro-anatomical parcellation shows human-like cerebral aging and medial hemispheric organization.
Cédric Girard-Buttoz, Patrick J Tkaczynski ... Catherine Crockford
Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.
Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.
Exploring tissue-specific regulation of gene expression with human-chimpanzee hybrid cells helps us understand how life evolves and what makes us human.
Experiments showed that uniformly white sclera, one distinguishing feature of human eyes, facilitates gaze perception across species, suggesting that this eye feature evolved for conspecific communication in humans.
Humans showed the most widespread asymmetric connectivity between the inferior parietal lobule subregions and the rest of the brain compared to macaques and chimpanzees, which shapes hemispheric specialization in primates.
