1,764 results found
    1. Cell Biology

    A cellular and molecular atlas reveals the basis of chytrid development

    Davis Laundon, Nathan Chrismas ... Michael Cunliffe
    Three-dimensional cell modelling, lipid analysis, transcriptomics, and live-cell imaging reveal biological insights in to the key stages of the chytrid fungus life cycle.
    1. Genetics and Genomics

    Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

    Leslie M Turner, Bettina Harr
    The genomic regions that cause male hybrids between house mouse subspecies to have low fertility have been identified.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Cell-type-specific cis-regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells

    Ban Wang, Alexander L Starr, Hunter B Fraser
    Exploring tissue-specific regulation of gene expression with human-chimpanzee hybrid cells helps us understand how life evolves and what makes us human.
    1. Evolutionary Biology

    Genetic transformation of Spizellomyces punctatus, a resource for studying chytrid biology and evolutionary cell biology

    Edgar M Medina, Kristyn A Robinson ... Nicolas E Buchler
    Spizellomycespunctatusis a genetically tractable chytrid and model organism for comparative cell biology for understanding evolution of the cell cycle, actin dynamics, and cellularization in fungi and early eukaryotes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast

    Sarah E Zanders, Michael T Eickbush ... Harmit Singh Malik
    Rapid acquisition of chromosome rearrangements, together with independently acting transmission distorter alleles on each chromosome, drive near complete sterility in fission yeast hybrids.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi

    Edgar M Medina, Jonathan J Turner ... Nicolas E Buchler
    Cell cycle network evolution in a fungal ancestor was punctuated by the arrival of a viral DNA-binding protein that was permanently incorporated into the regulatory network controlling cell cycle entry.
    1. Neuroscience

    Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

    Max L Sterling, Ruben Teunisse, Bernhard Englitz
    The accuracy of the Hybrid Vocalization Localizer (HyVL) brings a revolution to the study of social vocalizations of rodents and other animals, where vocalizations often occur in close proximity, and will empower downstream analysis of sequence and semantic analyses.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Admixture of evolutionary rates across a butterfly hybrid zone

    Tianzhu Xiong, Xueyan Li ... James Mallet
    Genetic barriers to gene flow maintain divergent linked substitution rates in hybridization.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

    Marc Kschonsak, Christine C Jao ... John C Tellis
    Cryogenic electron microscopy enables real-time structure-based drug design to advance the discovery of novel classes of small molecule inhibitors.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

    Sona Gregorova, Vaclav Gergelits ... Jiri Forejt
    Prdm9-generated meiotic asynapsis of homologous chromosomes in mouse subspecific hybrids causes hybrid sterility and can be reversed by introducing random stretches of consubspecific sequence (≥ 27Mb) on four chromosomes most sensitive to asynapsis.

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