189 results found
    1. Cell Biology
    2. Neuroscience

    KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring

    Noriko Homma, Ruyun Zhou ... Nobutaka Hirokawa
    Postnatal KIF2A is a key regulator for axon/dendrite determination of developing dentate granule cells, and its loss developed apical axons in dentate molecular layer, broke hippocampal wiring, and induced temporal lobe epilepsy.
    1. Computational and Systems Biology
    2. Neuroscience

    Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus

    Diego M Arribas, Antonia Marin-Burgin, Luis G Morelli
    Heterogeneity in the population of granule cells in the dentate gyrus, which includes immature and mature neurons with distinct intrinsic properties, contributes to the population's enhanced encoding capabilities and ability to discriminate correlated stimuli.
    1. Neuroscience

    All-trans retinoic acid induces synaptopodin-dependent metaplasticity in mouse dentate granule cells

    Maximilian Lenz, Amelie Eichler ... Andreas Vlachos
    All-trans retinoic acid increases the number of excitatory synapses in the dorsal hippocampus of mice and improves the ability of neurons to express synaptopodin-dependent synaptic plasticity.
    1. Neuroscience

    Sparse activity of identified dentate granule cells during spatial exploration

    Maria Diamantaki, Markus Frey ... Andrea Burgalossi
    Morphologically-mature granule cells with complex dendritic trees contribute to a sparse representation of space in the rat dentate gyrus.
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    1. Computational and Systems Biology
    2. Neuroscience

    T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells

    Marcel Beining, Lucas Alberto Mongiat ... Peter Jedlicka
    T2N, a novel interface between Matlab, TREES toolbox and NEURON, was used to generate compartmental models that reproduce the electrophysiology of dentate granule cells over a multitude of species, experimental conditions and developmental stages.
    1. Neuroscience

    Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells

    Yuntao Duan, Shih-Hsiu Wang ... Roman J Giger
    Mice that lack the autism susceptibility gene Semaphorin 5A show excess excitatory synapse formation in dentate granule neurons and also altered social behavior, adding to evidence that a surplus of synapses contributes to the behavioral changes observed in autism spectrum disorders.
    1. Neuroscience

    A dynamic clamp protocol to artificially modify cell capacitance

    Paul Pfeiffer, Federico José Barreda Tomás ... Susanne Schreiber
    Via the capacitance clamp, electrophysiologists can for the first time flexibly set an artificial membrane capacitance for neurons and other excitable cells and thereby adjust their membrane time constant independent of any conductance changes.
    1. Neuroscience

    Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

    Wei Deng, Mark Mayford, Fred H Gage
    By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
    1. Neuroscience

    Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

    Brian W Jones, Jennifer Deem ... G Stanley McKnight
    The PKA anchoring protein, AKAP7, localizes PKA in dentate granule mossy fibers and this localization plays an important role in contextual discrimination and cAMP-induced synaptic plasticity.
    1. Neuroscience

    Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells

    Ryan J Vaden, Jose Carlos Gonzalez ... Linda Overstreet-Wadiche
    Fast-spiking parvalbumin-expressing interneurons generate slow spillover-mediated GABAergic transmission to young adult-born and neighboring mature neurons of the dentate gyrus.

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