15,420 results found
    1. Microbiology and Infectious Disease

    An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey, Brad E Sleebs ... Christopher J Tonkin
    The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.
    1. Biochemistry and Chemical Biology

    Group II intron inhibits conjugative relaxase expression in bacteria by mRNA targeting

    Guosheng Qu, Carol Lyn Piazza ... Marlene Belfort
    Group II introns can target mRNA, causing inhibition of gene expression, as a potential driver for evolution to the spliceosome.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

    David S Booth, Yifan Cheng, Alan D Frankel
    The nuclear export receptor Crm1 cooperatively binds its HIV Rev-RRE cargo as a dimer using a species-specific interface that supports viral replication by enhancing nuclear export of HIV RNA.
    1. Ecology

    5α-cyprinol sulfate, a bile salt from fish, induces diel vertical migration in Daphnia

    Meike Anika Hahn, Christoph Effertz ... Eric von Elert
    A fish-derived bile salt was shown to act as interspecific infochemical, inducing the widespread predator avoidance behavior diel vertical migration at picomolar concentrations in freshwater zooplankton of the genus Daphnia.
    1. Chromosomes and Gene Expression

    piRNA-guided co-transcriptional silencing coopts nuclear export factors

    Martin H Fabry, Filippo Ciabrelli ... Benjamin Czech
    A member of the Drosophila Nuclear Export Factor (Nxf) family, Nxf2, forms part of the piRNA-dependent co-transcriptional silencing complex and is essential for transposon repression in fly ovaries.
    1. Neuroscience

    Forced choices reveal a trade-off between cognitive effort and physical pain

    Todd A Vogel, Zachary M Savelson ... Mathieu Roy
    Cognitive effort is aversive and people will accept physical pain to avoid it, but this avoidance does not appear to share the same fundamental characteristics of pain avoidance.
    1. Neuroscience
    2. Computational and Systems Biology

    A specific role for serotonin in overcoming effort cost

    Florent Meyniel, Guy M Goodwin ... Raphaël Gaillard
    A selective reuptake inhibitor shows a beneficial effect in healthy humans during an effort-benefit tradeoff task, mediated at the computational level by a specific alleviation of effort cost.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The deubiquitylase Ubp15 couples transcription to mRNA export

    Fanny Eyboulet, Célia Jeronimo ... François Robert
    Ubp15 regulates the ubiquitylation of the export adaptor Mex67.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

    Ian A Roundtree, Guan-Zheng Luo ... Chuan He
    YTHDC1 facilitates selective clearance of N6-methyladenosine methylated mRNAs from the nucleus to the cytoplasm through binding by nuclear 'reader' proteins and incorporation into the canonical mRNA export pathway.
    1. Computational and Systems Biology
    2. Neuroscience

    Trading mental effort for confidence in the metacognitive control of value-based decision-making

    Douglas G Lee, Jean Daunizeau
    Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.

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