Proteolytic cleavage of the extracellular matrix glycoprotein fibrillin-2 by the secreted metalloprotease ADAMTS6 influences skeletal development by modulating fibrillin microfibril abundance and GDF5/BMP signaling, illustrating the crucial role of extracellular matrix proteostatic mechanisms in growth factor regulation during morphogenesis.

A fibrillin-related protein, FBN-1, is a key component of the apical extracellular matrix and prevents epidermal cell deformation by biomechanical forces during morphogenesis of the C. elegans embryo.

APPPS1 microglia express disease-associated proteomic signatures of Alzheimer's disease earlier, compared to the APP-KI, and these differences correlate with the levels of fibrillar Aβ and impaired microglial phagocytic function.

Atomic structures of hIAPP fibrillar segments, determined using the cryo electron microscopy method MicroED, reveal that strong, stable intermolecular interactions are important features of cytotoxic amyloid proteins.

The equilibrium between solubility and aggregation of proteins in the nucleus is controlled by co-aggregates like RNA and the action of ATP as both an energy source and a destabilizing chemical agent.

Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.

Aβ inhibitors effectively block its aggregation, while also reducing seeding of tau aggregation from Aβ, tau, and AD derived fibrils, suggesting the two share a structurally related disease relevant interface.

Research carried out in the simple chordate Ciona has elucidated the regulatory interplay between two evolutionarily conserved transcription factors, Brachyury and Xbp1, and has shed new light on their roles in the formation of the notochord.

Nanoscale changes to individual collagen fibrils drive lung fibrosis.

Confocal imaging, electron microscopy, and genetic perturbations provide an unprecedented view of a complex and dynamic luminal matrix that determines tube shape during morphogenesis.