679 results found
    1. Evolutionary Biology

    Phylogenomic analyses of echinoid diversification prompt a re-evaluation of their fossil record

    Nicolás Mongiardino Koch, Jeffrey R Thompson ... Greg W Rouse
    Phylogenomics of sea urchins clarifies their origins and diversification history, reveals surprising discrepancies with their rich fossil record, and serves as basis to explore the sensitivity of time calibration analysis.
    1. Evolutionary Biology

    Ovipositor and mouthparts in a fossil insect support a novel ecological role for early orthopterans in 300 million years old forests

    Lu Chen, Jun-Jie Gu ... Olivier Béthoux
    Hundreds of fossil remains shed new light on the evolution of grasshoppers, gryllids, and katydids and their ecological role 300 million years ago.
    1. Evolutionary Biology

    Preservation of three-dimensional anatomy in phosphatized fossil arthropods enriches evolutionary inference

    Achim H Schwermann, Tomy dos Santos Rolo ... Thomas van de Kamp
    X-ray imaging reveals well-preserved internal characters in mineralized arthropods from the Paleogene, urging the reexamination of previously neglected fossil collections.
    1. Evolutionary Biology

    New fossils of Australopithecus sediba reveal a nearly complete lower back

    Scott A Williams, Thomas Cody Prang ... Lee R Berger
    Newly recovered lumbar vertebrae belonging to Malapa Hominin 2, an adult female of the fossil hominin species Australopithecus sediba, demonstrate that this individual was adapted to upright posture and bipedal locomotion but also had adaptations for climbing in trees.
    1. Medicine
    2. Neuroscience

    The importance of individual beliefs in assessing treatment efficacy

    Luisa Fassi, Shachar Hochman ... Roi Cohen Kadosh
    Participants' subjective beliefs about the treatment received in an intervention study can explain variability in mental health symptoms and cognition.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

    Karolina Honzejkova, Dalibor Kosek ... Tomas Obsil
    Thioredoxin functions as a negative allosteric effector of ASK1 by altering the interaction between the thioredoxin-binding and tetratricopeptide repeats domains, thereby reducing access to the kinase domain's activation segment.
    1. Cell Biology
    2. Developmental Biology

    Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

    Martina Rossi, Carlos Anerillas ... Myriam Gorospe
    The levels of the cytokine BAFF increase across senescence paradigms, in turn triggering a secretory phenotype in some senescent cells and activating p53 in other senescent cells.
    1. Evolutionary Biology

    Oldest skeleton of a fossil flying squirrel casts new light on the phylogeny of the group

    Isaac Casanovas-Vilar, Joan Garcia-Porta ... David M Alba
    Flying squirrels may have originated earlier than previously thought and remained unchanged for almost 12 million years.
    1. Developmental Biology

    N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

    Elif Kon, Elisa Calvo-Jiménez ... Yves Jossin
    FGFRs regulate multipolar cortical neuron orientation and the morphological change into bipolar cells in vivo under the control of N-Cadherin and the extracellular matrix protein Reelin.
    1. Evolutionary Biology

    New fossil remains of Homo naledi from the Lesedi Chamber, South Africa

    John Hawks, Marina Elliott ... Lee R Berger
    The discovery of new skeletal remains of Homo naledi in the Lesedi Chamber, South Africa, adds more evidence to our understanding of the morphology and behavior of this recently discovered species.

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