Psychosocial environments modulate genetic risk of asthma and other allergic diseases through altered peripheral blood gene expression.

Multiple replicated examples of epistasis affecting gene expression in humans are identified, some explaining a substantial proportion of the variation in expression.

Caffeine modulates the genetic risk for cardiovascular disease through changes in target gene expression, likely due to regulation of transcription factor binding.

A massively parallel reporter assay, mSTARR-seq, reveals widespread DNA methylation-environment interactions across the genome, prioritizing CpG sites identified in epigenome-wide association studies that may be most relevant to biological embedding.

Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.

Development of an enrichment method to facilitate RNA-sequencing of the Lyme disease pathogen from inside of ticks during a bloodmeal provides new candidates for genes important for disease transmission.

A combination of window-of-sensitivity, genetic, and in vitro findings illuminate mechanisms of gene–environment interaction in a multifactorial model of a common birth defect.

Ubp15 regulates the ubiquitylation of the export adaptor Mex67.

Analysis of molecular signatures of lifespan variation across wild yeast isolates revealed how Nature employs environment to modify genotype, gene expression, and metabolome to arrive at different lifespan, while preserving fitness in various ecological niches.

Mitochondrial respiratory chain dysfunction inhibits mitochondrial one-carbon metabolism, impairing cellular nucleotide biosynthesis.