132 results found
    1. Chromosomes and Gene Expression

    Comparative transcriptomics reveal a novel tardigrade-specific DNA-binding protein induced in response to ionizing radiation

    Marwan Anoud, Emmanuelle Delagoutte ... Jean-Paul Concordet
    When exposed to high-dose ionizing radiation, tardigrades undergo extensive DNA damage, like humans, but cope by stimulating expression of DNA repair proteins and of TDR1, a novel tardigrade-specific DNA-binding protein.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

    Rose T Byrne, Audrey J Klingele ... Michael M Cox
    Experiments on E. coli show that multiple mechanisms contribute to extreme resistance to ionizing radiation in bacteria, with mutations to three genes for DNA repair having a prominent role in one evolved population.
    1. Chromosomes and Gene Expression

    Tardigrades: Surviving extreme radiation

    Chaitra Shree Udugere Shivakumara Swamy, Thomas C Boothby
    Tiny animals known as tardigrades use a combination of DNA repair machinery and a novel protein to mend their genome after intense ionizing radiation.
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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Loss of foxo rescues stem cell aging in Drosophila germ line

    Filippo Artoni, Rebecca E Kreipke ... Hannele Ruohola-Baker
    Loss of foxo rescues age-related defects in stem cell-mediated regeneration post-injury.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    DNA Repair: Vive la résistance!

    Steven J Sandler
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    1. Chromosomes and Gene Expression

    The tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals

    Carolina Chavez, Grisel Cruz-Becerra ... James T Kadonaga
    Dsup, a unique protein found only in tardigrades, is a nucleosome-binding protein that protects DNA from damage by hydroxyl radicals, such as those generated by ionizing radiation or oxidants.
    1. Developmental Biology
    2. Genetics and Genomics

    Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

    Ananya Chakravarti, Heshani N Thirimanne ... Brian R Calvi
    Drosophila p53 protein isoforms function during oogenesis to ensure the integrity of the transmitted genome, a function that is conserved to humans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Bedrock radioactivity influences the rate and spectrum of mutation

    Nathanaëlle Saclier, Patrick Chardon ... Christophe J Douady
    Subterranean isopods endemic to regions with large igneous rock formations have a higher mutation rate and display an excess of mutations that are typical of an oxidative stress.
    1. Cancer Biology
    2. Cell Biology

    The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion

    Erwan Goy, Maxime Tomezak ... Corinne Abbadie
    Irradiation of normal human fibroblasts and mice in conditions mimicking standard external X-ray radiotherapy protocols highlights that noncancerous cells surrounding the planning target volume accumulate DNA single-strand breaks but almost no double-strand breaks, putting them in a pre-cancerous senescent state.
    1. Stem Cells and Regenerative Medicine

    ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

    Richard H Chapple, Tianyuan Hu ... Daisuke Nakada
    Estrogen is a systemic factor that promotes hematopoietic regeneration by activating the unfolded protein responses.

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