1,038 results found
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution and regulation of microbial secondary metabolism

    Guillem Santamaria, Chen Liao ... Joao B Xavier
    Strains of the bacterium Pseudomonas aeruginosa that use secondary metabolism to make surfactants and change the surface tension of the liquid that surrounds them do so only if they can first meet their primary metabolic needs.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Shearing in flow environment promotes evolution of social behavior in microbial populations

    Gurdip Uppal, Dervis Can Vural
    Shearing in fluid flow induces or enhances budding dispersal in microbial populations, resulting in stronger cooperative behavior.
    1. Computational and Systems Biology

    Calibration and analysis of genome-based models for microbial ecology

    Stilianos Louca, Michael Doebeli
    A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A timeline of bacterial and archaeal diversification in the ocean

    Carolina A Martinez-Gutierrez, Josef C Uyeda, Frank O Aylward
    Phylogenomics reveals the timeline over which marine bacteria and archaea colonized the oceans and shows the geological context of their diversification.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution

    Nicholas M Boffi, Yipei Guo ... Ariel Amir
    High-resolution simulations of evolving microbial populations reveal that microscopic epistasis slows the rate of adaptation, while clonal interference can either speed it up or leave it fixed.
    1. Ecology
    2. Genetics and Genomics

    Viral dark matter and virus–host interactions resolved from publicly available microbial genomes

    Simon Roux, Steven J Hallam ... Matthew B Sullivan
    From public microbial genomes, VirSorter revealed 12,498 viral genome sequences that expand the map of the global virosphere and whose analyses improve understanding of viral taxonomy, evolution and virus-host interactions.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Nanoscale resolution of microbial fiber degradation in action

    Meltem Tatli, Sarah Moraïs ... Itzhak Mizrahi
    Phenotypic heterogeneity at the single-cell level of cellulosomal machinery biosynthesis suggests a division-of-labor strategy as revealed by the nanoscale mechanistic and ecological investigation of in situ structure and distribution of cellulosomes on bacteria while interacting with the cellulosic substrate.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans

    Donato Giovannelli, Stefan M Sievert ... Costantino Vetriani
    The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO2 fixation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Core genes can have higher recombination rates than accessory genes within global microbial populations

    Asher Preska Steinberg, Mingzhi Lin, Edo Kussell
    Homologous recombination rates tend to be highest in the most conserved parts of bacterial genomes.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Artificial selection methods from evolutionary computing show promise for directed evolution of microbes

    Alexander Lalejini, Emily Dolson ... Luis Zaman
    Multiobjective artificial selection methods from evolutionary computing show promise for improving directed evolution outcomes when selecting for multiple traits of interest.

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