A one-photon three-dimensional light sculpture technique has been developed and demonstrated for high spatio-temporal resolution photostimulation and imaging of dozens of neurons in the intact mouse brain in vivo.

A new type of microscope reveals detail of organelles inside every cell in the entirety of an intact embryo or tissue region over 100 cubic millimeters in volume.

Fluorescence lifetime imaging microscopy, paired with fluorescent, voltage-sensitive dyes, provides a method for measuring and quantifying membrane potentials of living cells.

A properly designed two-photon fluorescence microscope allows high-resolution visualization of neurons and capillaries in healthy and diseased mouse retinas in vivo, while to visualize subcellular structures, adaptive optics is required to correct the eye-induced optical aberrations.

There is a systematic functional organization for curvature representation in area V4 where specific curvatures are encoded by unique values (modules) from the set of systematically represented values.

A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.

Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.

An all-optical 3D two-photon imaging and photostimulation platform was demonstrated, with the capability to precisely stimulate a large group of cells in mice cortex in vivo with low laser power.

A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.

Interactions between near but distinct (<1 mm) structures such as cortical layers in the rodent brain can be studied by a new micro-optical tool that is low-cost and capable of multilayer optical recordings, optogenetic stimulations, or both.