Florian Bleffert, Joachim Granzin ... Filip Kovacic
Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.
Yoshinori Hirano, Yong-Guang Gao ... Rhoderick E Brown
The C2-domain of cytoplasmic phospholipase A2α is structurally designed to target PC-rich membrane regions to increase the enzymatic efficiency of the catalytic domain, which prefers PCs with polyunsaturated acyl chains.
Bardet–Biedl syndrome 3 (BBS3) protein promotes phospholipase D to load onto the BBSome at the ciliary tip for moving out of the cilium via intraflagellar transport.
Michiel van Veen, Elisa Matas-Rico ... Wouter H Moolenaar
GDE3 is a transmembrane GPI-specific phospholipase C that sheds the urokinase receptor (uPAR) from the cell surface resulting in loss of uPAR function in breast cancer cells and reduced tumor growth.
See-Yeun Ting, Kaitlyn D LaCourse ... Joseph D Mougous
Pseudomonas aeruginosa defends against interbacterial antagonism through the coordinated expression of previously uncharacterized pathways that grant threat-specific protection.
SAA removes toxic products of lipolysis of the cell membrane by sPLA2, indicating that SAA and sPLA2 act synergistically to clear debris from injured sites, as required for tissue healing.
Sec14l3/SEC14L2 respond to upstream Wnt/Frizzled/Dvl stimulation to recruit and activate phospholipase Cδ4a (Plcδ4a) to further initiate calcium release.