Skin cells from a patient with retinitis pigmentosa have been used to generate induced pluripotent stem cells, which could potentially form the basis of new treatments for this disease.

Chimeric RNAs are widely distributed spatiotemporally during human retinal development and have important regulatory functions, such as silencing of CTNNBIP1-CLSTN1 biasing the progenitor cells toward the RPE cell fate at the expense of neural retinal cell fates.

The maturation of multi-potent immature cells in the larval eye in Drosophila is regulated by a transcription factor that displays unexpected heterogeneous dynamics during the cells’ transitions towards differentiated states.

Genetic and imaging analysis reveal that microglial precursors use ocular blood vessels as a pathway to enter the optic cup and subsequently infiltrate the retina preferentially through the neurogenic region.

Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.

NMNAT1, a ubiquitously expressed metabolic enzyme linked to inherited blinding disease, is crucial for the proper differentiation of photoreceptor cells and subsequent survival of multiple cell types in the retina.

Organoids are useful in studying guidance cues for retinal ganglion cell (RGC) axon generation and regeneration, and the method of RGC isolation via CNTN2 facilitates investigating RGC-related retinal diseases such as glaucoma.

Single-cell transcriptome analysis of the regenerating retina in adult zebrafish reveals molecular control steps during Müller glia stem cell activation, progressive differentiation, and neural regeneration.

Single-cell transcriptomic analysis of developing retinal ganglion cells in mice suggests that their diversification into 45 discrete types occurs via the gradual restriction of multipotential precursors.

Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.