1,011 results found
    1. Neuroscience

    Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools

    Remi Ronzano, Camille Lancelin ... Marco Beato
    Populations of spinal cord neurons innervate motoneurons controlling local and distant synergist and antagonist muscles.
    1. Cancer Biology

    Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

    Patricia L Theard, Erin Sheffels ... Robert L Kortum
    Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.
    1. Microbiology and Infectious Disease

    Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations

    Ashelyn E Sidders, Katarzyna M Kedziora ... Brian P Conlon
    Palmitoleic acid not only potentiates vancomycin killing of Gram-positive bacteria, but the insertion of palmitoleic acid into the membrane leads to the unexpected accumulation of membrane-bound cell wall precursors, representing a novel mechanism of action for unsaturated fatty acids.
    1. Neuroscience

    A synergy-based hand control is encoded in human motor cortical areas

    Andrea Leo, Giacomo Handjaras ... Emiliano Ricciardi
    The human brain encodes coordinated patterns of joint movements – synergies – to increase the efficiency with which it can control complex hand movements.
    1. Computational and Systems Biology
    2. Neuroscience

    Dissecting muscle synergies in the task space

    David O'Reilly, Ioannis Delis
    A novel network information framework quantifies muscle interactions, characterises their task-relevance, and identifies networks of muscles with similar and complementary functional roles.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections

    Morgan A Wambaugh, Steven T Denham ... Jessica CS Brown
    Identification and exploitation of interactions between the antifungal drug fluconazole and FDA- approved drugs has the potential to improve treatment for patients with difficult-to-treat systemic fungal infections.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deciphering the combinatorial landscape of immunity

    Antonio Cappuccio, Shane T Jensen ... Elena Zaslavsky
    The immune Synergistic/Antagonistic Interaction Learner (iSAIL) resource has the capacity to generate insight into combinatorial immunity, help guide hypothesis generation and further experimentation relevant to basic research and drug therapeutics.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks

    Connor J Balzer, Michael L James ... Brad J Nolen
    An activator of branching nucleation by Arp2/3 complex directly synergizes with an activator of linear filament nucleation to initiate assembly of actin networks that drive endocytosis.
    1. Biochemistry and Chemical Biology

    Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

    Nadinath B Nillegoda, Antonia Stank ... Bernd Bukau
    The emergence of complementary electrostatic potentials after the prokaryotic-to-eukaryotic split drives physical and functional cooperation between canonical class A and class B J-proteins to boost protein disaggregation.
    1. Neuroscience

    Synergism of type 1 metabotropic and ionotropic glutamate receptors in cerebellar molecular layer interneurons in vivo

    Jin Bao, Michael Graupner ... Isabel Llano
    During parallel fibre activity in vivo, postsynaptic mGluR1 receptors in molecular layer interneurons of the cerebellar cortex are engaged in a frequency-dependent manner and in concert with inotropic glutamate receptors.

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