An internal clock based on brain levels of dopamine works with the circadian clock to maintain daily patterns of alertness and activity, and may be implicated in the altered behavioral patterns seen in schizophrenia and bipolar disorder.

Two acid-sensing members of the degenerin/epithelial sodium channel family play distinct roles in controlling different aspects of rhythmic proton and calcium oscillations in the nematode intestine.

General stress response factors Msn2 and Msn4 activate glycolytic genes and promote acetyl-CoA accumulation to stimulate growth and proliferation of yeast cells under a nutrient-limiting condition, suggesting the unexpected interrelationship between carbohydrate metabolism and stress response.

A single night of sleep deprivation suppresses fighting behaviors in male fruit flies, with consequent impairments in reproductive fitness.

High triiodothyronine levels lead to a broad rewiring of the liver transcriptome, which mostly occurs downstream of the liver clock machinery itself, thus suggesting that daytime critically affects thyroid hormone action in the liver.

A computational model of the thalamocortical network explains sleep stages by the coordinated variations in the level of neuromodulators and predicts differences of sleep pattern in human, cat and mouse recordings.

Locally activatable bioluminescence (LABL) is a genetically encoded reporter that allows real time, in vivo measurement of distinct clocks in different cells and tissues in Drosophila.

Sleep-wake patterns, together with a suprachiasmatic nuclei-independent circadian factor, are necessary and sufficient to maintain high-amplitude nychthemeral rhythms in PERIOD-2.