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    1. Immunology and Inflammation

    Autoimmunity: Redoxing PTPN22 activity

    Magdalena Shumanska, Ivan Bogeski
    The oxidative state of a critical cysteine residue determines the enzymatic activity of a phosphatase involved in T-cell immune responses.
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    1. Biochemistry and Chemical Biology

    Genetic Code: Expanding codon size

    Tarana Siddika et al.
    Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.
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  1. Episode 80: May 2022

    In this episode, we hear about insulin and the body clock, communication in baboons, the sleep patterns of animals in the wild, a new species of dinosaur, and how Covid antibodies produced in response to vaccines and infection compare.
  2. A gloved hand holding a yellow spark on a grey background

    Ukraine: Holding lectures while the bombs fall

    With the Russian army marching on his home city, a Ukrainian scholar must decide how to respond.
  3. Research Culture: Welcome to the lab

    Andrey Andreev et al.
    Having a formal onboarding procedure for new lab members can lead to a happier and more productive working environment.
    1. Genetics and Genomics
    2. Medicine

    Cancer: The aging epigenome

    Brandon L Pierce
    A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
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    1. Neuroscience

    Learning: The devil is in the task structure

    Orit Nafcha, Uri Hertz
    Conflicting evidence about how the brain processes social and individual learning stems from which type of information is presented as the primary source of knowledge during experiments.
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  4. Point of View: Promoting constructive feedback on preprints with the FAST principles

    Sandra Franco Iborra et al.
    Ensuring that public feedback on preprints is focused, appropriate, specific and transparent (or FAST) will help to develop a thriving culture for reviewing and commenting on preprints.
    1. Neuroscience

    Perception: Where functional MRI stops, metabolism starts

    Polytimi Frangou, William T Clarke
    Combining techniques that track blood oxygenation and biochemicals during neuronal activity reveals how the brain computes perceived and unperceived stimuli.
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    1. Structural Biology and Molecular Biophysics

    Artificial Intelligence: Exploring the conformational diversity of proteins

    Avner Schlessinger, Massimiliano Bonomi
    An artificial intelligence-based method can predict distinct conformational states of membrane transporters and receptors.
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