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A new biologically-informed training paradigm enables protein language models to predict affinity maturation trajectories for antibodies.

Previously underappreciated folds in the cerebral cortex provide insight into how its structure varies across individuals.

Cocaine use disrupts the encoding of abstract states in the orbitofrontal cortex.

The biosynthesis of an important biopolymer called hyaluronan requires an enzyme that discriminates between two different substrates.

Patterns of neural activity called theta oscillations have a role in memory encoding but – contrary to current thinking – do not appear to have a role in memory retrieval.

The reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.

Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.

A lipoprotein called YbjP could be the answer to a puzzle about efflux pumps in gram-negative bacteria.

Gaining the ability to kill rival microbes is not always an advantage for bacteria in complex gut microbiomes.

Sharing positive and negative experiences at lab meetings can make a career in science a little less hard, a little more pleasant, and a little more human.