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    1. Cell Biology
    2. Neuroscience

    Vision: A pathway to sight

    Katherine J Wert
    The breakdown of glutamine is an important metabolic pathway for the health and survival of rod photoreceptors within the retina.
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    1. Neuroscience

    Synaptic Plasticity: A new mode of action for unconventional NMDA receptors

    Ikuko Smith
    Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.
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    1. Genetics and Genomics
    2. Neuroscience

    Pain: Epidermal cells and sensory neurons team up

    Jean-Christophe Boivin, Tomoko Ohyama
    Experiments in fruit fly larvae show that epidermal cells can communicate with sensory neurons to drive responses to pain.
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    1. Chromosomes and Gene Expression

    Gene Regulation: Linking O-GlcNAc and intron retention

    John A Hanover
    An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.
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    1. Cell Biology
    2. Developmental Biology

    Cell Signaling: Not all dimers are equal

    Jeet H Patel, Mary C Mullins
    Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.
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    1. Immunology and Inflammation

    Bacterial Clearance: With a little help from T cells

    Troy Burtchett, Neal Hammer
    Specific host factors, such as immune cell activity, sex hormones and microbiota composition, influence the ability of Staphylococcus aureus bacteria to colonize the gut of mice.
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  7. members of the coordinating team for the Brazilian Reproducibility Initiative

    Reproducibility: How replicable is biomedical science in Brazil?

    The results of a project to estimate the reproducibility of research in Brazil have just been published.
  8. Image of the female leafhopper Macrosteles quadrilineatus

    Episode 98: April 2025

    In this episode, we hear about parasites as molecular matchmakers, drug combinations and cancer treatment, chemical defences in poison frogs, the impact of education on brain structure, and what movies can reveal about the organisation of the infant visual system.
    1. Neuroscience

    Cognition: When working memory works for our goals

    Jacob A Miller
    When navigating environments with changing rules, human brain circuits flexibly adapt how and where we retain information to help us achieve our immediate goals.
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    1. Cancer Biology
    2. Cell Biology

    Breast Cancer: How cell crowding causes cancer cells to spread

    Rui Hua, Jean X Jiang
    Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
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