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    1. Neuroscience

    Experience-Dependent Plasticity: The little brain supervises learning in the big brain

    Martha Garcia, Mark Wagner
    Experiments on mice reveal how the cerebellum modulates plasticity in the somatosensory cortex.
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    1. Microbiology and Infectious Disease

    Tuberculosis: A surprising new hiding place for a dangerous pathogen

    Sheetal Gandotra, Yogendra Singh
    The bacterium that causes TB can hide in liver cells called hepatocytes, and reprogram their metabolism for its own benefit.
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  1. Blurry photo of a flag, fish and a bird in the water

    Episode 101: December 2025

    In this episode, we hear about the development of the visual system, nocebo effects versus placebos, cross-species insemination, telomere length, and efforts to recreate Darwin’s “warm little pond”.
    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral
    A new method for tracking the activity of individual neurons day after day in the growing brain has revealed a key developmental transition in neuronal activity.
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  2. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    A survey of more than 200 researchers shows strong support for a new community-driven lab handbook that can be implemented by individual group leaders to reduce conflict and create more positive and equitable work environments.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    The metabolic fate of a nutrient called pyruvate determines how big cells become.
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    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    Our latest Focus Issue looks at what we’ve learnt over the past decade and what’s next for the field of trained immunity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Focus Issue: Evolving our understanding of trained immunity

    Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer
    The articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit "trained immunity" for the development of new vaccines and therapeutics.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacteriology: How Shigella tackles host defences

    Yizhou Huang, Teresa LM Thurston
    The pathogenic bacteria Shigella avoids detection inside hosts cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
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