The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.

Human macrophages infected with Mycobacterium tuberculosis present peptides derived from substrates of type VII secretion systems on MHC class I via a pathway dependent on the ESX-1 secretion system and independent of antigen processing by the proteasome and cathepsins.

The activation of small-conductance calcium-activated potassium channels in spines by action potentials regulates the induction of spike-timing dependent synaptic plasticity during low-frequency single action potential–EPSP pairing.

Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.

Nucleosomes at enhancers are unusually dynamic and change histone turnover rates during differentiation.

Finch embryos are laid at an earlier stage than other avian embryos and contain cells with similar properties to pluripotent embryonic stem cells from mice.

Large-scale developmental defects in mice occur with the ablation of the epithelial-specific splicing factors Esrp1 and Esrp2.

Blastocyst complementation of rat embryos with donor mouse embryonic stem cells was used to simultaneously produce multiple, donor-derived hematopoietic and stromal cells in the interspecies bone marrow that exhibited normal gene expression signatures, cell surface markers, and functional characteristics.

Oct1 replaces Oct4 at critical targets shortly after ESC differentiation to promote expression of lineage-specific genes and repress lineage-inappropriate genes.

Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.