2,484 results found
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson, Xiao-Li Bing ... Nicolas Buchon
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Neuroscience

    An open-source device for measuring food intake and operant behavior in rodent home-cages

    Bridget A Matikainen-Ankney, Thomas Earnest ... Alexxai V Kravitz
    An open-source behavioral platform allows for operant, feeding, and circadian experiments in rodent home-cages.
    1. Medicine
    2. Neuroscience

    Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum

    Alex Reichenbach, Rachel E Clarke ... Zane B Andrews
    Hunger-sensitive AgRP neurons must sense changes in calorie availability to transmit metabolic information into dopamine release in the NAc and dorsal striatum, albeit over different time frames, to increase motivated food reward seeking.
    1. Developmental Biology

    Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

    Georges Raad, Fabrizio Serra ... Valerie Grandjean
    Predisposition to obesity-associated diseases is dependent on the ancestors' diet.
    1. Neuroscience

    Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans

    Satoshi Higurashi, Sachio Tsukada ... Kentaro Noma
    A screen of lactic acid bacteria reveals that diet modulates the age-dependent decline of thermotaxis behavior in C. elegans without changing the organismal lifespan.
    1. Immunology and Inflammation

    MicroRNAs of the miR-17~92 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression

    Xiang Zhang, Jianguo Liu ... Xiaoyu Hu
    miR-17~92 family of miRNAs control the balance between pro- and anti-inflammatory cytokines in adipose tissue macrophages, the absence of which leads to disturbed adipose homeostasis.
    1. Immunology and Inflammation
    2. Medicine

    Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

    Yufang Ding, Karin Yanagi ... Arul Jayaraman
    A microbiome metabolite alleviates liver steatosis and inflammation, and shows its potential as a therapeutic modality for non-alcoholic fatty liver disease.
    1. Immunology and Inflammation

    Homeostatic activation of aryl hydrocarbon receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration

    Adeline Cros, Alba De Juan ... Elodie Segura
    Lack of aryl hydrocarbon receptor ligands in the diet of mice increases the inflammatory state in their epidermis, making cutaneous allergic reactions more severe and airway allergy more pronounced after skin sensitization.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Role of the pre-initiation complex in Mediator recruitment and dynamics

    Elisabeth R Knoll, Z Iris Zhu ... Randall H Morse
    Genome-wide recruitment of Mediator and Pol II is reduced in yeast lacking the Med2-Med3-Med15 tail module triad, and Mediator association with gene promoters depends on Pol II, Taf1, and TBP.
    1. Developmental Biology
    2. Neuroscience

    UPRER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

    Pengfei Liu, Xinyi Liu, Bin Qi
    The cellular stress response pathway helps animals evaluate food quality and regulate feeding behavior to adapt in nutrient-deficient environments.

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