11 results found
    1. Neuroscience

    Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

    Bhanu Shrestha, Jiun Sang ... Youngseok Lee
    Uncovering pharyngeal sour taste receptors in Drosophila melanogaster reveals a novel mechanism for detecting ingested carboxylic acids, expanding understanding of how insects internally sense and respond to appetitive tastants.
    1. Neuroscience

    Cholesterol taste avoidance in Drosophila melanogaster

    Roshani Nhuchhen Pradhan, Craig Montell, Youngseok Lee
    Fruit flies detect cholesterol through ionotropic receptors in taste, leading to active avoidance despite dietary necessity.
    1. Neuroscience

    A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster

    Jiun Sang, Subash Dhakal ... Youngseok Lee
    Fruit flies have special neurons in their pharynx with ionotropic receptors to prevent consuming too much salt, which was confirmed using a variety of behavioral and physiological assays.
    1. Cell Biology

    Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

    Tokiro Ishikawa, Makoto Kashima ... Kazutoshi Mori
    The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.
    1. Neuroscience

    Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons

    Darya Task, Chun-Chieh Lin ... Christopher J Potter
    Olfactory neurons of insects, once thought to express only a single type of olfactory receptor, exhibit widespread co-expression of receptors from multiple chemosensory gene families.
    1. Developmental Biology

    Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

    Rodrigo M Young, Thomas A Hawkins ... Stephen W Wilson
    Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
    1. Neuroscience

    Molecular basis of fatty acid taste in Drosophila

    Ji-Eun Ahn, Yan Chen, Hubert Amrein
    Molecular-genetic, neural imaging and behavioral analyses reveal how Drosophila melanogaster sense fatty acids, important nutrient compounds, through multimeric Ionoptropic Receptors complexes.
    1. Developmental Biology

    scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities

    Yong-Il Kim, Rebecca O'Rourke, Charles G Sagerström
    Combined single nucleus RNAseq and ATACseq enabled the first molecular resolution of all hindbrain rhombomeres, the derivation of a unique gene regulatory network for each rhombomere, and the identification of gene expression changes as rhombomeres form from early progenitor pools.
    1. Immunology and Inflammation

    Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

    Chongbin Hu, Nan Zhang ... Jian-zhong Shao
    scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.
    1. Chromosomes and Gene Expression

    Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

    Srivarsha Rajshekar, Jun Yao ... Mary Goll
    Derepression of transcripts from hypomethylated pericentromeric repeats triggers an innate immune response in an animal model of Immunodeficency, Centromere and Facial anomalies (ICF) syndrome.

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