DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to microtubules and regulating the composition of dynein/dyactin/JIP3 motor complex.
A novel strategy is described for stimulating a large number of Müller glia to proliferate in mice by manipulating cell cycle components without a damage stimulus.
p27Kip1 directly controls invadopodia turnover by promoting the interaction of PAK1 with Cortactin, which induces Cortactin phosphorylation, invadopodia disassembly and facilitates invasion through extracellular matrix.
Joseph Pickering, Kavitha Chinnaiya, Matthew Towers
A cell cycle timing mechanism similar to one operating in cultured adult oligodendrocyte progenitor cells controls the growth and patterning of the embryonic chick wing bud.
In quiescent yeast, a stable bundle of parallel microtubules is assembled from the centrosome by an original multistep mechanism that follows a precise temporality and involves Aurora B and various kinesins.
BLOS1 is a new regulator of LDLR endosomal recycling through coordinating kinesins during long-range transport, and depletion of BLOS1 in mouse liver leads to aberrant lipid metabolism.