369 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe

    Anneke Hibbel, Aliona Bogdanova ... Jonathon Howard
    The budding yeast kinesin Kip2 is a polymerase that uses its processive motility in a positive feedback loop to promote microtubule growth.
    1. Cell Biology

    Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

    Xiaoqin Fu, Lu Rao ... Judy Shih-Hwa Liu
    DCX negatively regulates dynein-mediated retrograde transport through two critical interactions by regulating dynein binding to microtubules and regulating the composition of dynein/dyactin/JIP3 motor complex.
    1. Cell Biology

    Reconstitution of kinetochore motility and microtubule dynamics reveals a role for a kinesin-8 in establishing end-on attachments

    Julia R Torvi, Jonathan Wong ... Georjana Barnes
    Kip3, a kinesin-8, has a role in chromosome congression as shown by reconstitution of kinetochore and microtubule dynamics.
    1. Cell Biology
    2. Computational and Systems Biology

    Remote control of microtubule plus-end dynamics and function from the minus-end

    Xiuzhen Chen, Lukas A Widmer ... Yves Barral
    A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.
    1. Stem Cells and Regenerative Medicine

    Simultaneous cyclin D1 overexpression and p27kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina

    Zhifei Wu, Baoshan Liao ... Wenjun Xiong
    A novel strategy is described for stimulating a large number of Müller glia to proliferate in mice by manipulating cell cycle components without a damage stimulus.
    1. Cancer Biology
    2. Cell Biology

    p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

    Pauline Jeannot, Ada Nowosad ... Arnaud Besson
    p27Kip1 directly controls invadopodia turnover by promoting the interaction of PAK1 with Cortactin, which induces Cortactin phosphorylation, invadopodia disassembly and facilitates invasion through extracellular matrix.
    1. Developmental Biology

    An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development

    Joseph Pickering, Kavitha Chinnaiya, Matthew Towers
    A cell cycle timing mechanism similar to one operating in cultured adult oligodendrocyte progenitor cells controls the growth and patterning of the embryonic chick wing bud.
    1. Cell Biology
    2. Computational and Systems Biology

    Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

    Alison L Kearney, Dougall M Norris ... James G Burchfield
    Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.
    1. Cell Biology

    A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit

    Damien Laporte, Aurelie Massoni-Laporte ... Isabelle Sagot
    In quiescent yeast, a stable bundle of parallel microtubules is assembled from the centrosome by an original multistep mechanism that follows a precise temporality and involves Aurora B and various kinesins.
    1. Cell Biology

    BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

    Chang Zhang, Chanjuan Hao ... Wei Li
    BLOS1 is a new regulator of LDLR endosomal recycling through coordinating kinesins during long-range transport, and depletion of BLOS1 in mouse liver leads to aberrant lipid metabolism.

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