569 results found
    1. Physics of Living Systems

    Active torque generation by the actomyosin cell cortex drives left–right symmetry breaking

    Sundar Ram Naganathan, Sebastian Fürthauer ... Stephan W Grill
    The actomyosin cytoskeleton generates active chiral torques that lead to left-right asymmetry in C. elegans embryos.
    1. Physics of Living Systems

    Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking

    Pedro Sampaio, Sara Pestana ... Susana Santos Lopes
    Zebrafish have a physiological time-window of 1 hr for breaking left-right symmetry and are highly sensitive to the left-right organizer anterior fluid mechanics rather than to the nature of its fluid content.
    1. Structural Biology and Molecular Biophysics

    Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A

    James Lincoff, Cole VM Helsell ... Michael Grabe
    Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
    1. Physics of Living Systems

    Epithelial colonies in vitro elongate through collective effects

    Jordi Comelles, Soumya SS ... Daniel Riveline
    Spontaneous elongation of epithelial colonies is related to the orientation of the mean nematic cell elongation field, as shown and tested with experiments and theory.
    1. Cell Biology
    2. Physics of Living Systems

    Centering and symmetry breaking in confined contracting actomyosin networks

    Niv Ierushalmi, Maya Malik-Garbi ... Kinneret Keren
    Novel mechanisms for cellular centering and symmetry breaking involving persistent contractile actomyosin flows and their hydrodynamic interactions with the fluid cytosol are presented and studied using a minimal, reconstituted system.
    1. Neuroscience

    Reinforcement biases subsequent perceptual decisions when confidence is low, a widespread behavioral phenomenon

    Armin Lak, Emily Hueske ... Adam Kepecs
    Confidence-dependent reinforcement learning is active and produces trial-to-trial choice updating even in well-learned perceptual decisions without explicit reward biases, across species and sensory modalities.
    1. Neuroscience

    Visual homogeneity computations in the brain enable solving property-based visual tasks

    Georgin Jacob, RT Pramod, SP Arun
    Seemingly disparate property-based tasks (oddball search, same-different and symmetry) are solved by computing a novel image property, visual homogeneity, which is localized to the object selective cortex.
    1. Physics of Living Systems

    The younger flagellum sets the beat for Chlamydomonas reinhardtii

    Da Wei, Greta Quaranta ... Daniel SW Tam
    External hydrodynamic forcing on each flagellum of Chlamydomonas reinhardtii reveals a leader-follower relation between the two flagella in the synchronous beating.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Physical limits of flow sensing in the left-right organizer

    Rita R Ferreira, Andrej Vilfan ... Julien Vermot
    Large-scale in vivo imaging of the zebrafish left-right organizer (Kupffer's vesicle) combined with fluid dynamics calculations allows to quantitatively test the possible flow detection mechanisms and supports the flow transport of chemical signals as the mechanism of side determination.
    1. Physics of Living Systems

    Learning developmental mode dynamics from single-cell trajectories

    Nicolas Romeo, Alasdair Hastewell ... Jörn Dunkel
    A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.

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