A generalizable approach to understanding the logic of molecular recognition reveals the contributions of individual residues to the specificity of protein-protein interactions.

Most regenerated cells after β-cell damage in zebrafish are Insulin+ Somatostatin+ bihormonal cells that are functional and able to restore glucose control.

In Drosophila oocytes, the exclusion of the scaffold protein PAR3 from the posterior cortex depends on PAR1 and endocytosis, while its anterior localisation requires microtubules and recycling endosomes.

Par3 is polarized in the plane of the vertebrate neural plate, binds and recruits Prickle3 to the apical membrane and promotes the formation of core planar cell polarity complexes.

Baz/Par3 and Sanpdo are required for clustering and activation of Notch receptors to allow intra-lineage private communication following asymmetric division of Drosophila epithelial cells.

The phenotype of mutant potassium channels described here allows the mechanistic dissection of the complex process of potassium channel gating in the pathology-relevant KCNH family.

Representation of sound lateralisation and intensity by neural population in the rat auditory cortex strongly depends on the brain state suggesting that the neural tuning to lateralisation is not hard-wired.

Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.

Genetic and microscopy analyses identify a programmed cell death mechanism that kills a cell subpopulation in a bacterial biofilm where oxygen is limiting, thereby promoting dispersion of newborn motile cells through the action of DNA released by dead cells.