Signalling and metabolic interactions of the plant energy organelles, chloroplasts and mitochondria, depend on the nuclear regulatory protein RCD1.

SND1 has m6A-reading ability and is essential for Kaposi's sarcoma-associated lytic replication.

Cellular and genetic approaches reveal that exposure of a normally buried nuclear export signal (NES)-like sequence mediates export of ALS-linked mutant and misfolded wild-type SOD1 to the cytoplasm by CRM1.

Unbiased transcriptomics reveals novel insights into the mechanisms that may contribute to regional neurodegeneration in SCA1, and other SCAs in general.

How do the metal cofactors present in the protein SOD1 collaborate with the interacting membrane to define the role of this protein in the disease ALS?

PPM1D-mutant leukemia cells exhibit a dysregulated redox landscape, a diminished response to oxidative stress, and rely on SOD1 for their survival.

Palmitoylation recruits the phosphatase SCP1 to endothelial cell membranes where it negatively regulates Akt kinase activity, resulting in suppressed angiogenesis and decreased tumorigenesis.

Solution NMR spectroscopy reveals the energy landscape of immature Cu, Zn-superoxide dismutase and leads to atomic resolution structural models of transiently populated non-native oligomers.

The novel role of Adgrf1 in the progression of fatty liver was revealed and targeting Adgrf1 is a promising therapeutic strategy for treating NAFLD patients.

Studies in a mouse model of spinocerebellar ataxia type 1 show that a protein called capicua stabilizes toxic ataxin-1 oligomers offering a possible explanation for regional patterns of neurodegeneration.