11,274 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

    Tim Stuart, Steven R Eichten ... Ryan Lister
    Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.
    1. Neuroscience

    Catecholaminergic modulation of meta-learning

    Jennifer L Cook, Jennifer C Swart ... Roshan Cools
    A human psychopharmacology study reveals that a drug that affects the dopamine and noradrenaline systems enhances people's ability to adapt their learning rate to suit the volatility of the environment.
    1. Genetics and Genomics

    Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae

    Tingting Zhao, Irina O Vvedenskaya ... Craig D Kaplan
    Ssl2 processivity determines the window for transcription start site selection during promoter scanning by RNA polymerase II in Saccharomyces cerevisiae.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Cell-type-specific cis-regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells

    Ban Wang, Alexander L Starr, Hunter B Fraser
    Exploring tissue-specific regulation of gene expression with human-chimpanzee hybrid cells helps us understand how life evolves and what makes us human.
    1. Neuroscience

    Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding

    Stuart L Johnson
    Mammalian primary sensory inner hair cells play an active role in auditory information processing, such that they show a preference for either timing or intensity coding.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

    Marc A Kerenyi, Zhen Shao ... Stuart H Orkin
    Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Quality control of transcription start site selection by nonsense-mediated-mRNA decay

    Christophe Malabat, Frank Feuerbach ... Alain Jacquier
    RNA polymerase II generates numerous transcript isoforms, including transcripts initiating downstream of the START codon, that are efficiently degraded by the nonsense-mediated mRNA decay pathway.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

    Jinrui Dong, Sivakumar Viswanathan ... Stuart A Cook
    IL6ST (gp130) binding proteins, such as HyperIL6, promote liver regrowth in a STAT3-indpependent manner through competitive inhibition of anti-regenerative IL11 signaling.
    1. Neuroscience

    Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action

    Jennifer C Swart, Monja I Froböse ... Hanneke EM den Ouden
    Motivational coupling of action to reward and inhibition to punishment is subserved by dissociable learning and choice processes, and is modulated by dopamine/noradrenaline transporter blockade.
    1. Evolutionary Biology

    The evolution of division of labour in structured and unstructured groups

    Guy Alexander Cooper, Hadleigh Frost ... Stuart Andrew West
    The evolution of division of labour with non-accelerating returns from specialisation can occur for several reasons, including but not limited to topologically constrained group structures, but there must always be a group efficiency benefit and a coordination mechanism is required.

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