44 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

    Yilin Kang et al.
    A novel and metazoan-specific protein, Tim29, is identified as a subunit of the human TIM22 complex and shown to function in the assembly of hTim22 and facilitate contacts with the TOM complex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

    Niels Denkert et al.
    Channel characteristics of the presequence translocation pore have a direct impact on protein import into the mitochondrial matrix.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

    Rupa Banerjee et al.
    Two domains of the peripheral membrane protein Tim44 interact with two different sectors of a translocase to coordinate the translocation of proteins across the inner mitochondrial membrane.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23

    See-Yeun Ting et al.
    The motor that drives preproteins into the mitochondrial matrix is coupled to the translocase by Tim44, a two-domain scaffold protein with an intrinsically disordered "dynamic arm" and a structurally stable anchoring domain.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase

    Keren Demishtein-Zohary et al.
    First two transmembrane segments of Tim17 are involved in interaction with the channel and the second two with the motor of the presequence translocase suggesting how proteins are handed over during their translocation into mitochondria.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes

    Corinne von Känel et al.
    Mitochondrial inner membrane translocation of presequence-containing proteins by the single bifunctional TIM complex of T. brucei requires an non-canonical J domain-containing protein.
    1. Cell Biology

    Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

    Weilin Zhang et al.
    Mitophagy regulates mitochondrial quality and mediates extensive mitochondrial degradation in (patho-)physiological settings and is one of the key components of hypoxic preconditioning which protects the heart from ischemia/reperfusion injury.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis

    Tatsuhisa Tsuboi et al.
    Mitochondria can tune the protein synthesis of nuclear-encoded proteins through condition-dependent mRNA localization that is regulated by translation elongation and the geometric constraints of the cell.
    1. Cell Biology

    Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

    Yilin Kang et al.
    A neuronal specific function of the mitochondrial chaperone, hTim8a in Complex IV biology provides insight into the pathomechanisms underlying the mitochondrial disease, Mohr-Tranebjaerg syndrome.
    1. Cell Biology

    PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

    Stefania Monterisi et al.
    The enzyme phosphodiesterase 2A2 localises at the mitochondrial membrane and its inhibition results in a local increase in cAMP concentration, mitochondrial elongation and resistance to apoptosis.

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