234 results found
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

    Charlotte Lässig et al.
    RIG-I Singleton-Merten syndrome mutations either mimic or freeze the protein in an ATP-bound state and lead to autoimmune signalling through a gain-of-function recognition of self-RNA.
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

    Yoko Ogawa et al.
    PDGFRα+ Sca-1+ bone marrow stromal/stem cells in whole bone marrow grafts can trigger the onset of autoimmune-related fibrosis in a mouse model of scleroderma.
    1. Immunology and Inflammation

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

    Yasunobu Arima et al.
    Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

    Sara E Vazquez et al.
    Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
    1. Immunology and Inflammation

    Autoimmunity: Treating type-1 diabetes with an epigenetic drug

    Yohko Kitagawa, Naganari Ohkura
    Insight
    Available as:
    • HTML
    • PDF
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Cell Biology
    2. Immunology and Inflammation

    Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception

    Stefanie Gryzik et al.
    A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

    Xue-Song Zhang et al.
    Alteration of host gut microbiota by antibiotic exposure in early life remodeled host intestinal immune development and metabolism and enhanced the induction of type 1 diabetes in genetically predisposed animals.
    1. Cell Biology
    2. Immunology and Inflammation

    ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

    Charlotte Lässig et al.
    Mutations within the ATPase domain of RIG-I in patients with Singleton-Merten Syndrome prevent ATP-hydrolysis dependent dissociation of RIG-I from double-stranded RNA and lead to unintentional constitutive signaling through increased binding of endogenous RNA.
    1. Immunology and Inflammation

    Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

    Wenxian Fu et al.
    A short treatment of the NOD mouse model of type-1 diabetes with I-BET151, a small molecule bromodomain blocker, provides long-term protection from disease by inducing macrophages to adapt an anti-inflammatory tenor whilst promoting islet β cell regeneration.

Refine your results by:

Type
Research categories