539 results found
    1. Epidemiology and Global Health

    Risk factors relate to the variability of health outcomes as well as the mean: A GAMLSS tutorial

    David Bann, Liam Wright, Tim J Cole
    We provide a tutorial to use GAMLSS, applied using cohort data to study how risk factors may influence both the mean and variability of body mass index and mental health.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

    Oliver Stirrup, Joseph Hughes ... Judith Breuer
    Epidemiological and viral sequence data can be combined to provide standardised feedback on cases of hospital onset COVID-19 infection that would be useful for infection prevention and control.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart, Philip K Maini, Robin N Thompson
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Epidemiology and Global Health

    Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics

    Irving Cancino-Muñoz, Mariana G López ... Iñaki Comas
    Low-burden does not mean low local transmission, and tailor-made strategies are needed to control TB based on the knowledge of the local transmission dynamics.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Understanding drivers of phylogenetic clustering and terminal branch lengths distribution in epidemics of Mycobacterium tuberculosis

    Fabrizio Menardo
    Populations of Mycobacterium tuberculosis associated with clustering and shorter terminal branches are not necessarily transmitting more.
    1. Medicine
    2. Microbiology and Infectious Disease

    Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study

    Mohamed Abbas, Anne Cori ... Stephan Harbarth
    Nosocomial transmission of SARS-Cov-2 in geriatric settings is complex, with different patterns between patients and healthcare workers working in Covid/non-Covid wards that should be taken into account when designing infection control strategies.
    1. Ecology
    2. Epidemiology and Global Health

    Microbiome-pathogen interactions drive epidemiological dynamics of antibiotic resistance: A modeling study applied to nosocomial pathogen control

    David RM Smith, Laura Temime, Lulla Opatowski
    A novel mathematical modeling framework for antibiotic-resistant bacteria combining within-host microbiome-pathogen interactions with population-level pathogen epidemiology, demonstrating how antibiotic consumption and ecological competition come together to drive the spread of resistance.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols

    Paul Z Chen, Niklas Bobrovitz ... Frank X Gu
    Broader case variation in respiratory viral load, and in shedding virus via droplets and aerosols, for SARS-CoV-2 than influenza A(H1N1)pdm09 facilitates greater transmission heterogeneity in the COVID-19 pandemic than the 2009 flu pandemic.
    1. Genetics and Genomics
    2. Medicine

    GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

    Michael Chong, Pedrum Mohammadi-Shemirani ... Guillaume Paré
    An ethnically robust pipeline for inferring mitochondrial DNA copy number from genotyping arrays was developed and applied to the UKBiobank, elucidating several common and rare loci in genes involved in the synthesis, maintenance, and organization of mitochondrial DNA.
    1. Medicine
    2. Epidemiology and Global Health

    Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households

    Samuel PC Brand, Patrick Munywoki ... David James Nokes
    Targeting the mothers, and other household members, of newborns with a mixture of respiratory syncytial virus (RSV) vaccines is both efficient and effective at reducing RSV hospitalizations.

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