2,266 results found
    1. Genetics and Genomics
    2. Neuroscience

    A genetic, genomic, and computational resource for exploring neural circuit function

    Fred P Davis, Aljoscha Nern ... Gilbert L Henry
    Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.
    1. Neuroscience

    Accelerating with FlyBrainLab the discovery of the functional logic of the Drosophila brain in the connectomic and synaptomic era

    Aurel A Lazar, Tingkai Liu ... Yiyin Zhou
    FlyBrainLab is an open-source computing platform that integrates 3D exploration and visualization of diverse Drosophila connectomic/synaptomic datasets with interactive exploration of the functional logic of modeled executable brain circuits.
    1. Neuroscience

    Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

    Surjeet Mastwal, Xinjian Li ... Kuan Hong Wang
    Frontal cortical circuit alterations and cognitive deficits identified in mouse genetic models are reversed by chemogenetic or optogenetic stimulation of the mesocortical dopamine circuit in an adolescent period.
    1. Neuroscience

    ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition

    Sebastian Molina-Obando, Juan Felipe Vargas-Fique ... Marion Silies
    A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.
    1. Computational and Systems Biology
    2. Neuroscience

    Genetic control of encoding strategy in a food-sensing neural circuit

    Giovanni Diana, Dhaval S Patel ... QueeLim Ch'ng
    Building on previous work (Entchev et al, 2015), computational analyses reveal that the choice between redundant versus synergistic encoding in a gene expression code for food abundance is controlled by cross-talk and auto-regulation among TGF-beta and serotonin pathways.
    1. Developmental Biology
    2. Neuroscience

    Genetic transformation of structural and functional circuitry rewires the Drosophila brain

    Sonia Sen, Deshou Cao ... K VijayRaghavan
    Large-scale changes in the brain's functional circuitry can be brought about by simple changes in gene expression in neural stem cells during development.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase

    Lloyd Davis, Inja Radman ... Sebastian Greiss
    A method combining optimised genetic code expansion and optogenetics allows dissection of neural circuits with single-cell precision in freely moving animals.
    1. Neuroscience

    P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila

    Eric D Hoopfer, Yonil Jung ... David J Anderson
    A sexually dimorphic circuit node controls a persistent, internal state that promotes fighting and mating in Drosophila, revealing parallels with mammalian systems suggestive of a conserved circuit "motif" controlling social behaviors.
    1. Neuroscience

    The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2

    Pierre-Louis Ruffault, Fabien D'Autréaux ... Christo Goridis
    The location of neurons responsible for increasing the breathing rate upon detecting elevated levels of CO2 in the blood has been pinpointed to the retrotrapezoid nucleus in the brainstem.
    1. Neuroscience

    A circuit mechanism for the propagation of waves of muscle contraction in Drosophila

    Akira Fushiki, Maarten F Zwart ... Akinao Nose
    Coordinated activation and deactivation of inhibitory neurons triggers sequential muscle contractions that enable fruit fly larvae to propel themselves backwards and forwards.

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