DunedinPACE is a novel DNA methylation biomarker of the pace of biological aging for intervention trials and natural experiment studies investigating how the rate of aging may be changed by behavioral or drug therapy, or by environmental modification.

A signaling pathway involving PGAM5, ASK1 and JNK induces persistent FoxO activation, chaperone expression and lifespan extension following developmental mitochondrial stress, which can be blocked by mTOR signaling through GCN-2.

Comprehensive decade-long analysis of point-of-care resources reveals insights into how clinical research makes its way into practice across different medical specialties and through time to enable us to identify potential translational bottlenecks in the pathway from research to practice.

Descending inhibition of nociception from the brain has been identified in Drosophila larvae, for the first time in non-mammalian organisms.

Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.

In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.

Resting state spinal fMRI will be useful in studies of normal spinal cord function and central nervous system disorders.

Endogenous synthesis of fatty acids by oligodendrocytes is essential for development and repair in the central nervous system.

The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.