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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

    Stanley Nithianantham, Brian D Cook ... Jawdat Al-Bassam
    TOG (tumor overexpressed gene) domains organize then polymerize tubulins at microtubule plus ends.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes

    Roee Ben Nissan, Eliya Milshtein ... Ron Milo
    Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO2.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets

    David M Curran, Alexandra Grote ... John Parkinson
    A genome scale model of Brugia malayi metabolism illustrates a dynamic reliance on energy production pathways across its life cycle and identifies new drugs with experimentally supported anti-parasitic properties.
    1. Microbiology and Infectious Disease

    An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Michael J Coffey, Brad E Sleebs ... Christopher J Tonkin
    The Toxoplasma parasite requires an enzyme called ASP5 to cleave proteins for export into host cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells

    Scott M Emrich, Ryan E Yoast ... Mohamed Trebak
    Gene knockout in cell lines and mice reveal that store-operated calcium entry is synergistically mediated by Orai1 and Orai3 channel proteins in B cells and is important for signaling to the nucleus and metabolic activity in response to antigenic stimulation.
    1. Developmental Biology

    Steroidogenesis and androgen/estrogen signaling pathways are altered in in vitro matured testicular tissues of prepubertal mice

    Laura Moutard, Caroline Goudin ... Christine Rondanino
    Although complete mouse in vitro spermatogenesis can be achieved, failure of adult Leydig cell development, with accumulation of progesterone and estradiol, androstenedione deficiency, deregulation of steroidogenic, and steroid target gene expression, were highlighted in organotypic cultures, even with hCG.
    1. Cell Biology

    Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes

    Sakshi Shambhavi, Sudipta Mondal ... Rajan Sankaranarayanan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity

    Xue-Song Zhang, Jackie Li ... Martin J Blaser
    Alteration of host gut microbiota by antibiotic exposure in early life remodeled host intestinal immune development and metabolism and enhanced the induction of type 1 diabetes in genetically predisposed animals.
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