331 results found
    1. Physics of Living Systems

    Muscle-specific economy of force generation and efficiency of work production during human running

    Sebastian Bohm, Falk Mersmann ... Adamantios Arampatzis
    During human running, the soleus muscle was found to operate as work generator under optimal conditions for work production (high force-length potential and enthalpy efficiency) while the vastus lateralis promoted tendon energy storage and economical force generation (high force-length-velocity potential).
    1. Physics of Living Systems
    2. Neuroscience

    How human runners regulate footsteps on uneven terrain

    Nihav Dhawale, Madhusudhan Venkadesan
    When running on uneven terrain, humans mostly rely on the body's mechanical response for stability instead of planning their footsteps to seek out level ground.
    1. Ecology

    Mass enhances speed but diminishes turn capacity in terrestrial pursuit predators

    Rory P Wilson, Iwan W Griffiths ... David M Scantlebury
    Increased mass enhances speed but compromises turning capacity in pursuit predators; this has widespread ramifications for the best strategies for predators and prey during chases according to their relative masses.
    1. Computational and Systems Biology

    Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

    Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
    Recurrent spiking networks that process input stimuli with optimal efficiency have key emerging properties that are similar to those of biological neural networks.
    1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr, Irene Alfaras ... Rafael de Cabo
    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
    1. Neuroscience

    Effects of noise and metabolic cost on cortical task representations

    Jake Patrick Stroud, Michal Wojcik ... Mate Lengyel
    The dynamical solutions exhibited by task-optimized recurrent neural networks, and their similarity to prefrontal cortex dynamics, depends strongly on the strength of neural noise and metabolic cost imposed during training.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang, Gerd Bobe ... Adrian F Gombart
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Structural Biology and Molecular Biophysics

    Work minimization accounts for footfall phasing in slow quadrupedal gaits

    James R Usherwood, Zoe T Self Davies
    The range of footfall patterns seen in walking amphibians, reptiles and mammals, including hippopotamus, horse and (inverted) sloth, are consistent with simple principles of mechanical work minimization.
    1. Computational and Systems Biology
    2. Neuroscience

    Population adaptation in efficient balanced networks

    Gabrielle J Gutierrez, Sophie Denève
    Neural populations may depend on balanced recurrent connectivity to produce an efficient stimulus representation while also maintaining an accurate stimulus encoding despite the variability introduced by adapting neural responses.
    1. Computational and Systems Biology
    2. Neuroscience

    Tuning movement for sensing in an uncertain world

    Chen Chen, Todd D Murphey, Malcolm A MacIver
    Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.

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