1,763 results found
    1. Microbiology and Infectious Disease

    Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

    Dipasree Hajra, Raju S Rajmani ... Dipshikha Chakravortty
    SIRT1 and SIRT3-mediated immunometabolic shift governs intracellular Salmonella proliferation both in vitro and in vivo and dissemination in mice, thereby influencing the infection outcomes.
    Version of Record
    Research Article
    • Valuable
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan, Rebecca Rojansky ... David C Chan
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources

    Bram Cerulus, Abbas Jariani ... Kevin J Verstrepen
    Live-cell microscopy and genome-wide screens reveal how slow transitions in metabolism can underlie metabolic memory, providing a model for organisms demonstrating similar history-dependent behaviour and routes to improve industrial microbes.
    1. Neuroscience

    Maturation of metabolic connectivity of the adolescent rat brain

    Hongyoon Choi, Yoori Choi ... Dong Soo Lee
    Rat brains mature to increase metabolic connectivity between network components and establish energy efficiency in the midline structures from childhood to early adulthood.
    1. Neuroscience

    In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation

    Philémon Roussel, Mingyi Zhou ... Auguste Genovesio
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cancer Biology
    2. Genetics and Genomics

    Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

    Jianing Xu, Ed Reznik ... A Ari Hakimi
    A distinct class of kidney tumors is characterized not by patterns of somatic mutations, but by a distinct metabolism.
    1. Medicine

    Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

    Hong Zheng, Qianjin Li ... Cheng-Kui Qu
    The balanced utilization of energy sources, namely carbohydrates and fats, by mitochondria, is critically important for the long-term maintenance of both skeletal muscle and heart health.
    1. Cell Biology
    2. Neuroscience

    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

    Rene Solano Fonseca, Patrick Metang ... Peter M Douglas
    Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.
    1. Cell Biology

    Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

    Robert J Tower, Emily Busse ... Mimi C Sammarco
    Metabolic supplementation attenuates age-dependent declines in regeneration.
    1. Medicine

    Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

    Rebecca C Schugar, Christy M Gliniak ... Jonathan Mark Brown
    Small molecule inhibitors of gut microbial choline trimethylamine lyase activity protect against obesity.

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