24 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Extensive transmission of microbes along the gastrointestinal tract

    Thomas SB Schmidt, Matthew R Hayward ... Peer Bork
    Microbial populations are continuous along the gastrointestinal tract, with increased transmission in colorectal cancer and rheumatoid arthritis patients.
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment

    Xi Zhang, Xiaolin Zhang ... Yaling Han
    After myocardial infarction, gut microbiota affects platelet aggregation rate by regulating the absorption and metabolism of ticagrelor.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein, Floyd E Dewhirst, Daniel Segrè
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance

    Rene Niehus, Esther van Kleef ... Ben S Cooper
    A data-driven within-host model reveals that different antibiotics are associated with divergent effects on antibiotic resistance carriage and abundance in hospitalised patients, with important implications for antibiotic stewardship.
    1. Immunology and Inflammation

    Macrophages regulate gastrointestinal motility through complement component 1q

    Mihir Pendse, Haley De Selle ... Lora V Hooper
    Gut macrophages produce complement component C1q, which modulates neurogenic activity of gut peristalsis and is thus a key regulator of gastrointestinal motility.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response

    Sydney Lavoie, Kara L Conway ... Ramnik J Xavier
    Gnotobiotic and conventional mouse models of the IBD ATG16L1T300A SNP reveal gene-microbiota-immune interactions.
    1. Microbiology and Infectious Disease

    The impact of different antimicrobial exposures on the gut microbiome in the ARMORD observational study

    Leon Peto, Nicola Fawcett ... A Sarah Walker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

    Alannah Lejeune, Chunyi Zhou ... Ken Cadwell
    Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.
    1. Neuroscience

    Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

    Mar Gacias, Sevasti Gaspari ... Patrizia Casaccia
    Gut microbiota can influence mPFC transcriptional profiles and myelin content, overriding the impact of genetic background in the development of social avoidance behavior.
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

    Fangyan Wang, Xiujie Liu ... Wantie Wang
    Gut microbiota-derived gamma-aminobutyric acid is identified as a key metabolite that metformin protect from hepatic ischemia/reperfusion injury.

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