A novel mechanism by which a compartment-specific AAA+ complex mediating organelle biogenesis and protein quality control staves off induction of selective autophagy.

The Dictyostelium discoideum TRAF6 homolog TrafE coordinates the autophagy and ESCRT membrane repair machineries and works in the major cell-autonomous restriction pathway to control Mycobacterium marinum intracellular infection.

Hydrogen-deuterium exchange, electron microscopy, and vesicle reconstitution show how binding of the autophagy adaptor NDP52 to the FIP200 subunit of the ULK1 complex triggers membrane binding in autophagy.

Two GAP proteins bound to mitochondria regulate the enyzme Rab7, and thereby the expansion of the isolation membrane during mitophagy, downstream of PINK1 and Parkin, two proteins that are mutated in familial Parkinson's disease.

Upon AMPK activation by acute glucose restriction, Atg14p shifts its distribution from ER exit sites to liquid-ordered membrane domains on the vacuolar surface where, together with Atg6p, it facilitates LD-specific autophagy (i.e., microautophagy of lipid droplets) for energy production and long-term survival of starved cells.

Defense-related selective autophagy mediated by the antimicrobial autophagy cargo receptor NBR1/Joka2 is diverted to pathogen penetration sites to restrict plant colonization by the oomycete pathogen Phytophthora infestans.

WASp is an immunometabolic regulator of human myeloid cells and regulates autophagy and mitochondrial homeostasis.

H₂O₂-induced phosphorylation at Ser232 of Pex14 spatiotemporally regulates peroxisomal import of catalase, functioning in counteracting action against oxidative stress by the increase of cytosolic catalase.

This work validates PIP4K gamma as pharmacological target to ameliorate Huntington's disease.