92 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Reduced signal for polygenic adaptation of height in UK Biobank

    Jeremy J Berg, Arbel Harpak ... Graham Coop
    Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

    Mashaal Sohail, Robert M Maier ... Shamil R Sunyaev
    Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation after a sudden change in environment

    Laura Katharine Hayward, Guy Sella
    A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation from standing genetic variation allows rapid ecotype formation

    Nico Fuhrmann, Celine Prakash, Tobias S Kaiser
    Baltic and Arctic ecotypes of the marine midge Clunio emerged from a recent adaptive radiation, which is based on standing genetic variation at many loci involved in time-keeping and nervous system development.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Archaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas

    Giulia Ferraretti, Paolo Abondio ... Marco Sazzini
    A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.
    1. Developmental Biology
    2. Evolutionary Biology

    An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice

    João PL Castro, Michelle N Yancoskie ... Yingguang Frank Chan
    Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci

    Fan Han, Minal Jamsandekar ... Leif Andersson
    Hundreds of loci underlying ecological adaptation to different environmental conditions show striking differences in allele frequencies between ecotypes of Atlantic herring.
    1. Evolutionary Biology

    The population genetics of convergent adaptation in maize and teosinte is not locally restricted

    Silas Tittes, Anne Lorant ... Jeffrey Ross-Ibarra
    Adaptation of domesticated maize and its wild relative teosinte has been facilitated by the geographically widespread exchange of beneficial alleles between them.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolution of cytokine production capacity in ancient and modern European populations

    Jorge Domínguez-Andrés, Yunus Kuijpers ... Mihai G Netea
    Neolithic was a turning point for immune responses in Europeans, favoring tolerance against intracellular pathogens, promoting inflammation against extracellular microbes, and being related to current auto-immune diseases.
    1. Ecology
    2. Evolutionary Biology

    Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila

    Heather E Machado, Alan O Bergland ... Dmitri A Petrov
    Seasonal selection is a general feature of Drosophila melanogaster genetic variation, occurring in North American and European populations and affecting large proportions of the genome.

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