1,456 results found
    1. Computational and Systems Biology

    Learning predictive cognitive maps with spiking neurons during behavior and replays

    Jacopo Bono, Sara Zannone ... Claudia Clopath
    Predictive cognitive maps can be learned during behavior and replays using in spiking neurons.
    1. Physics of Living Systems

    Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer

    Yang Joon Kim, Kaitlin Rhee ... Hernan G Garcia
    The combination of theoretical modeling and quantitative live imaging revealed that the repressor proteins work cooperatively or anti-cooperatively depending on enhancer architecture.
    1. Cancer Biology
    2. Computational and Systems Biology

    Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

    Jonathan Rodriguez, Abdon Iniguez ... Richard A Van Etten
    A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.
    1. Neuroscience

    Using recurrent neural network to estimate irreducible stochasticity in human choice behavior

    Yoav Ger, Moni Shahar, Nitzan Shahar
    Applying deep learning tools to pinpoint predictive gaps in behavioral cognitive modeling.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston, Joerg P Burgstaller ... Nick S Jones
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Epidemiology and Global Health

    Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations

    Katharine Sherratt, Hugo Gruson ... Sebastian Funk
    A large collaborative project combined many different researchers' forecasts of COVID-19 across Europe, making predictions used in policy more reliable.
    1. Computational and Systems Biology

    A model-based analysis of the health impacts of COVID-19 disruptions to primary cervical screening by time since last screen for current and future disruptions

    Emily A Burger, Inge MCM de Kok ... Megan A Smith
    Despite the overall impact of COVID-19-related cervical cancer screening disruptions on cervical cancer outcomes being small, disruptions disproportionately affect underscreened women, underpinning the importance of reaching such women as a critical area of focus, regardless of temporary disruptions.
    1. Computational and Systems Biology
    2. Neuroscience

    Statistical context dictates the relationship between feedback-related EEG signals and learning

    Matthew R Nassar, Rasmus Bruckner, Michael J Frank
    The P300, an electroencephalography (EEG) component known to be evoked by surprising events, predicts learning in a bidirectional manner that depends critically on the surrounding statistical context.
    1. Neuroscience

    Evidence for embracing normative modeling

    Saige Rutherford, Pieter Barkema ... Andre F Marquand
    A brain chart database, containing functional and structural normative models, was tested to compare normative modeling features to raw features across three benchmarking tasks including group difference testing, classification, and regression.
    1. Cancer Biology
    2. Computational and Systems Biology

    Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

    Simon Grund Sørensen, Amruta Shrikhande ... Jakob Skou Pedersen
    Deficiencies of several DNA damage response genes can be predicted by their association with genome-wide mutation patterns.

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