6,510 results found
  1. Living Science: Love writing

    Eve Marder
    Clear writing is the key to success in science.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Polycomb enables primitive endoderm lineage priming in embryonic stem cells

    Robert S Illingworth et al.
    Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.
    1. Developmental Biology
    2. Neuroscience

    Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

    Menghao Lu, Kota Mizumoto
    Genetic analyses revealed the critical role of local Wnt in neuronal patterning by instructing neurite pruning.
    1. Neuroscience

    Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing

    Jun Kunimatsu et al.
    Neuronal activity in the striatum keeps track of elapsed time during the time production task while that in the cerebellum correlates with stochastic variation of self-timing in the range of several hundreds of milliseconds.
    1. Cell Biology
    2. Developmental Biology

    Patronin governs minus-end-out orientation of dendritic microtubules to promote dendrite pruning in Drosophila

    Yan Wang et al.
    A minus-end-binding stabilizes minus-end-out microtubules in dendrites, which are required for dendrite-specific pruning during neuronal remodelling.
    1. Cell Biology
    2. Neuroscience

    Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines

    Sonia Afroz et al.
    Extrasynaptic GABAA receptors that emerge at puberty trigger adolescent synaptic pruning; pruning is prevented and cognition is impaired if the receptors are absent.
    1. Neuroscience

    Endocannabinoid dynamics gate spike-timing dependent depression and potentiation

    Yihui Cui et al.
    The molecular mechanisms beyond the bidirectionality (tTLP and tLTD) of endocanabinoid spike-timing dependent synaptic plasticity have been identified.
    1. Evolutionary Biology
    2. Neuroscience

    Recalibrating timing behavior via expected covariance between temporal cues

    Benjamin J De Corte et al.
    Rats act as if they expect that the delays associated with temporal cues will covary due to a common causal factor.
    1. Neuroscience

    Sexual Differentiation: A matter of timing

    Michael W Perry, Claude Desplan
    A genetic pathway involved in development works together with the sex-determination pathway to control the timing of sexually dimorphic neural development in C. elegans.
    Insight
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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming

    Miriam Samstein et al.
    Inflammatory monocytes carry live Mycobacteria from the lung to draining lymph nodes and acquire many characteristics of dendritic cells but fail to stimulate proliferation of CD4 T cells.

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