Identification of distinct yolk sac-derived macrophage subpopulations in the fetal liver reveals their crucial role in shaping the hematopoietic niche, impacting erythropoiesis and granulopoiesis through direct interactions with long-term hematopoietic stem cells.

Loss-of-function variants of human ACK1 and BRK kinase underlie systemic lupus erythematosus in young patients from multiplex families and disrupt the anti-inflammatory response of macrophages to apoptotic cells.

A new mode of inflammasome regulation was discovered through a mouse strain intercross that identified the Pycard locus was associated with IL-1β release, and gene editing showed this was due to an SNP in the Pycard mRNA regulating its turnover.

Adult zebrafish Langerhans cells are derived from hematopoietic stem/progenitor cells but not Erythro-myeloid progenitors.

A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.

A new type of skin perivascular macrophages with extramedullary origin, access to blood and exclusive anti-inflammatory reparative properties has been characterized.

Thymic macrophages are unique phagocytes with antigen-presenting abilities that comprise a Timd4⁺ subset of embryonic origin located in the cortex and a Cx3cr1⁺ subset derived from adult hematopoietic stem cells residing in the medulla.

A combination of genetic fate-mapping and parabiotic experiments reveals the chronological expansion of yolk-sac-derived renal tissue-resident macrophages with age by cellular proliferation and recruitment from circulating progenitors.

Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.

Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a platform for the design of cell therapies.