14,620 results found
    1. Microbiology and Infectious Disease

    Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected human, macaque, and canine hosts, and allows accurate monitoring of parasite load following treatment

    Brooke E White, Carolyn L Hodo ... Rick L Tarleton
    A vastly improved PCR-based approach provides a long-sought test of cure and parasite load monitoring tool for Chagas disease.
    1. Medicine
    2. Microbiology and Infectious Disease

    Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study

    Barnaby Flower, Le Manh Hung ... Graham S Cooke
    Shortened hepatitis C therapy, with retreatment if needed, can reduce antiviral drug use in patients with mild liver disease, but day 2 viral load is not an adequate predictor of outcome.
    1. Medicine

    US women screen at low rates for both cervical and colorectal cancers than a single cancer: a cross-sectional population-based observational study

    Diane M Harper, Melissa Plegue ... Ananda Sen
    Only about half of women 50–64 years old are up-to-date for both cervical and colorectal cancer screening.
    1. Neuroscience

    The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Cristina Segalin, Jalani Williams ... Ann Kennedy
    The Mouse Action Recognition System is a computational pipeline for automated classification of social behaviors in freely interacting mice, accompanied by a graphical interface for analysis of multimodal neuroscience datasets.
    1. Medicine
    2. Microbiology and Infectious Disease

    HIV-1 DNA predicts disease progression and post-treatment virological control

    James P Williams, Jacob Hurst ... John Frater
    Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.
    1. Neuroscience

    Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses

    Gülçin Vardar, Andrea Salazar-Lázaro ... Christian Rosenmund
    A mutant rescue approach in STX1-null autaptic neurons provides definitive answers and opens up new questions into a controversial matter of syntaxin-1's binding to Munc18-1 through its N-peptide and its function in neurotransmission.
    1. Neuroscience

    Exogenous capture accounts for fundamental differences between pro- and antisaccade performance

    Allison T Goldstein, Terrence R Stanford, Emilio Salinas
    The detection of a salient stimulus triggers a stereotypical oculomotor response, an impulse to look toward it, whose timing and strength are largely independent of behavioral significance and top-down control.
    1. Neuroscience

    Cerebellar implementation of movement sequences through feedback

    Andrei Khilkevich, Juan Zambrano ... Michael Dean Mauk
    The cerebellum can learn a sequence of responses by using a feedback signal from the previous movement to learn the next one.
    1. Neuroscience

    DYT1 dystonia increases risk taking in humans

    David Arkadir, Angela Radulescu ... Yael Niv
    Patients with DYT1 dystonia show aberrant risk-aversion in a simple decision-making task, in accordance with predictions of a reinforcement learning model of corticostriatal trial-and-error learning.
    1. Neuroscience

    Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

    Jessie R Scheimann, Rachel D Moloney ... James P Herman
    Development of a conditional glucocorticoid receptor knockdown rat model allows for high resolution anatomical, physiological and behavioral exploration into the role of glucocorticoid receptor signaling in defined cell populations.

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