Shortened hepatitis C therapy, with retreatment if needed, can reduce antiviral drug use in patients with mild liver disease, but day 2 viral load is not an adequate predictor of outcome.
The Mouse Action Recognition System is a computational pipeline for automated classification of social behaviors in freely interacting mice, accompanied by a graphical interface for analysis of multimodal neuroscience datasets.
Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.
Gülçin Vardar, Andrea Salazar-Lázaro ... Christian Rosenmund
A mutant rescue approach in STX1-null autaptic neurons provides definitive answers and opens up new questions into a controversial matter of syntaxin-1's binding to Munc18-1 through its N-peptide and its function in neurotransmission.
Allison T Goldstein, Terrence R Stanford, Emilio Salinas
The detection of a salient stimulus triggers a stereotypical oculomotor response, an impulse to look toward it, whose timing and strength are largely independent of behavioral significance and top-down control.
Patients with DYT1 dystonia show aberrant risk-aversion in a simple decision-making task, in accordance with predictions of a reinforcement learning model of corticostriatal trial-and-error learning.
Jessie R Scheimann, Rachel D Moloney ... James P Herman
Development of a conditional glucocorticoid receptor knockdown rat model allows for high resolution anatomical, physiological and behavioral exploration into the role of glucocorticoid receptor signaling in defined cell populations.