Biochemistry

eLife publishes research spanning chemical biology and enzymology to metabolism and membrane proteins. Decisions are made by journal editors who are active researchers in biochemistry.

Latest articles

    1. Biochemistry

    Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

    Jonathan B Steinman et al
    Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency.
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    1. Biochemistry
    2. Microbiology and Infectious Disease

    A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

    Niels Bradshaw et al
    Structures of active and inactive conformations of a PP2C family phosphatase reveal a conserved switch that controls enzymatic activity and point to an unexpected relationship between phosphatases and proteasomal proteases.
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    1. Biochemistry
    2. Genes and Chromosomes

    Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

    Davide Normanno et al
    In concert phosphorylation site modification of both XRCC4 and XLF C-terminal disordered tails promotes disassembly of XRCC4/XLF DNA tethers during c-NHEJ.
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

    Justin M Jenson et al
    Short peptides that bind tightly to anti-apoptotic protein Bfl-1 but not other Bcl-2 family members provide a tool for diagnosing cancer cell survival mechanisms and a lead for developing new therapeutics.
    Research Article
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    1. Biochemistry
    2. Biophysics and Structural Biology

    Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation

    Hannah Steinert et al
    The discontinuous speed of transcription enables riboswitch molecules to adopt meta-stable structures in response to the presence of their cognate ligand, thereby gene-regulation by means of structure induced transcription termination can occur.
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    1. Biochemistry
    2. Plant Biology

    RISC-interacting clearing 3’- 5’ exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana

    Zhonghui Zhang et al
    AGO protein-interacting exoribonucleases clear RNA induced silencing complex (RISC)-resulting 5' cleavage products in time to recycle RISC and miRNAs.
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    1. Biochemistry
    2. Microbiology and Infectious Disease

    A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

    Fiona J Tooke et al
    Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.
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