Biochemistry

eLife publishes research spanning chemical biology and enzymology to metabolism and membrane proteins. Decisions are made by journal editors who are active researchers in biochemistry.

Latest articles

    1. Biochemistry
    2. Cell Biology

    Affimers proteins are versatile and renewable affinity reagents

    Christian Tiede et al.
    The Affimer technology represents renewable binding reagents for molecular biology, which provides research scientists and industry with an alternative to the recently criticised use of animal-produced antibodies.
    Tools and Resources
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    1. Biochemistry
    2. Developmental Biology and Stem Cells

    Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

    Sandip Chorghade et al
    A poly(A) tail-based regulatory mechanism dynamically controls PABPC1 protein synthesis in cardiomyocytes and thereby titrates cellular translation in response to developmental and hypertrophic cues.
    Research Article
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    1. Biochemistry
    2. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
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    1. Biochemistry
    2. Developmental Biology and Stem Cells

    Cardiac Hypertrophy: A tail of translational regulation

    Gillian A Gray, Nicola K Gray
    An RNA-binding protein called PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.
    Insight
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    1. Biochemistry

    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

    Sungki Hong et al.
    LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1.
    Research Article
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    1. Biochemistry

    Serine ADP-ribosylation reversal by the hydrolase ARH3

    Ivan Ahel et al.
    1. Biochemistry

    Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

    Jonathan B Steinman et al
    Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency.
    Research Article Updated
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