Biochemistry

Biochemistry

eLife publishes research spanning chemical biology and enzymology to metabolism and membrane proteins. Decisions are made by journal editors who are active researchers in biochemistry.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry
    2. Biophysics and Structural Biology

    Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

    Marcello Clerici et al.
    Structural, biochemical, and proteomic analyses of a four-subunit core module of the cleavage and polyadenylation specificity factor complex reveal its molecular architecture and specific determinants of polyadenylation signal recognition in human mRNAs.
    1. Biochemistry
    2. Cancer Biology

    Reproducibility in Cancer Biology: Getting to grips with c-Myc

    Dirk Eick
    The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
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    1. Biochemistry
    2. Cancer Biology

    Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

    L Michelle Lewis et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.
    1. Biochemistry

    eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

    Pilar Martin-Marcos et al.
    Substitutions in general translation initiation factor eIF1A found as recurring somatic mutations in uveal melanoma destabilize the closed conformation of the preinitiation complex at the start codon and increase discrimination against suboptimal initiation codons genome-wide.
    1. Biochemistry
    2. Biophysics and Structural Biology

    In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

    Megan C Kopp et al.
    Quantitative FRET UPR induction assay is used to measure IRE1 and BIP association and dissociation by a variety of ER misfolded proteins and by an important BiP substrate-binding domain mutant, significantly enhancing the evidence for the allosteric UPR induction model.
    1. Biochemistry

    RNA-dependent RNA targeting by CRISPR-Cas9

    Steven C Strutt et al.
    1. Biochemistry
    2. Biophysics and Structural Biology

    Structural basis of proton translocation and force generation in mitochondrial ATP synthase

    Niklas Klusch et al.
    Cryo-EM reveals atomic details of two membrane half-channels for translocation of protons that drive rotary catalysis in ATP synthase.
    1. Biochemistry
    2. Cell Biology

    SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a

    Hui Jing et al.
    A new post-translational regulatory mechanism of K-Ras is identified, which expands the function of reversible protein lysine fatty acylation and offers new possibility to target the K-Ras oncoprotein.

Highlights

    1. Biochemistry

    How bacteria keep proteins moving

    Conrad W Mullineaux
    1. Biochemistry

    Transitioning to DNA genomes in an RNA world

    Razvan Cojocaru, Peter J Unrau
    1. Biochemistry

    Post-translational modifications: Reversing ADP-ribosylation

    Giuliana Katharina Moeller, Gyula Timinszky

Senior editors

  1. Philip Cole
    Senior Editor
  2. Ivan Dikic
    Senior Editor
  3. Andrea Musacchio
    Senior Editor
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