Browse our latest Biochemistry and Chemical Biology articles

Biochemical data demonstrate that the conformation of the target site DNA can dramatically modulate the kinetics and directionality of the otherwise isoenergetic transposition reaction of DDE transposases.

The ability of the Ndc80 complex to bind two Dam1 complex rings is important for chromosome attachment, and the distance between the two rings is vital for supporting growth.

Stalling spliceosome assembly at a novel step before Bact complex formation reveals new insights into the extensive RNP rearrangements and compositional changes that accompany the intricate process of spliceosome activation.

BCL9/Legless is an integral component of the Wnt enhanceosome, harboring binding sites in its conserved C-terminus for multiple core components of this complex including ChiLS and Groucho/TLE.

The crystal structures of the key vaccine candidate CyRPA alone and in complex with antibody Fab fragment was solved and this will be important information for designing a vaccine.

Sin1, a regulatory subunit of TOR protein kinase, has an evolutionarily conserved domain that specifically binds and recruits substrate for phosphorylation, and may represent a potential target for anti-cancer drugs.

A domain called the 'Conserved region in the middle' is responsible for target recognition in the TORC2 complex in fission yeast and the mTORC2 complex in mammals.

Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.

A new mechanism is uncovered by which the RNF168 ubiquitin ligase couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.

An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.