Daniela Justa-Schuch, Maria Silva-Garcia ... Ruth Geiss-Friedlander
Cleavage of Syk, a central kinase in B-cell signalling, by DPP9 leads to Syk degradation, identifying novel roles for DPP9 in Syk signaling and in the N-end rule pathway.
Shun-Hsiao Lee, Lissa Nicola Princz ... Christian Biertümpfel
The crystal structure of human Holliday junction resolvase GEN1 in complex with DNA reveals a conserved chromodomain as an additional DNA-anchoring point that opens new perspectives for enzyme regulation.
PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.
Cosimo Pinto, Kristina Kasaciunaite ... Petr Cejka
The nuclease of hDNA2 limits its processive DNA unwinding capacity; the helicase function becomes stimulatory when hDNA2 is in complex with BLM or WRN helicase to degrade dsDNA.
Min-Kyung Sung, Tanya R Porras-Yakushi ... Raymond J Deshaies
Tom1 is the ubiquitin ligase in yeast that anchors a protein quality control pathway that rapidly eliminates ribosomal proteins that fail to assemble into ribosomes.
Amrita Rai, Anastasia Oprisko ... Matthias P Müller
A human three-helix Rab-binding domain can potentially bind to two Rab proteins simultaneously with different affinities at binding sites generated by gene duplication.
The structure of the catalytic core of the N6-methyladenosine RNA methyltransferase complex METTL3-METTL14 reveals that METTL3 is the catalytic subunit, while METTL14 plays non-catalytic roles in substrate recognition and in maintaining complex integrity.
