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LAMP proteins, the major glycoproteins of the lysosome membrane, bind cholesterol directly and specifically, and interact with NPC1 and NPC2 proteins as part of the lysosomal cholesterol export process.

Thioredoxin-Interacting Protein binds directly to fructose transporters and regulates fructose metabolism, both acutely and chronically.

Activation by amino acids causes mTORC1 to translocate transiently to the lysosomal surface.

Molecular simulations can capture key aspects of the conformational exchange in a protein.

The C9orf72 expansion binds and sequesters the splicing factor hnRNP H leading to insoluble G-quadruplex aggregates that functionally reduce hnRNP H, thereby producing splicing defects.

Storage of solar energy in the thylakoid electrical field by photosynthesis in vivo can substantially destabilize charge-separated states in photosystem II, leading to singlet oxygen production and photodamage, contributing to loss of productivity, especially under fluctuating light experienced in the field.

A cell-free reaction that reconstitutes the selective sorting of a miRNA into exosomes reveals an RNA-binding protein, YBX1, as a critical sorting factor.

The α1 isoform of synGAP restricts the binding of AMPA-receptors and other regulatory proteins to PSD-95, and thus regulates synaptic strength.

Cleavage of Syk, a central kinase in B-cell signalling, by DPP9 leads to Syk degradation, identifying novel roles for DPP9 in Syk signaling and in the N-end rule pathway.