Browse our latest Biochemistry and Chemical Biology articles

An archaeal basal transcription factor containing an iron-sulphur cluster sheds light on the evolution of transcription machineries in archaea and eukaryotes.

A multidimensional chemical mapping strategy enables confident determination of the structures of non-coding RNAs at 1-nm resolution, including previously intractable riboswitch and human regulon states.

A new potent and selective CDK9 inhibitor induces the expression of the proto-oncogene MYC via a mechanism that depends on the bromodomain protein BRD4.

Pol II-mediated transcription and chromatin looping of CDKN1A are repressed by MAF1 through the regulation of Pol III activity.

ULK3 is a kinase in the abscission checkpoint that temporarily inactivates ESCRT-III proteins via phosphorylation, which is required to delay cytokinesis in response to defects in mitosis.

Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.

A detailed model of the T7 replisome with the precise positions of the helicase and polymerase at the replication fork explains how catalysis by the two enzymes is coordinated.

Ire1α co-opts the Sec61 translocon channel to efficiently cleave its mRNA substrates during endoplasmic reticulum stress conditions.

Single molecule DNA unzipping reveals a novel model for the regulation of transcription factors and nucleosome positioning via nucleosome remodeling in yeast.