Browse our latest Biochemistry and Chemical Biology articles

Elevated methionine levels, or a shortage of nitrogen or iron, induce terrein production in the fungus Aspergillus terreus.

Atomic structures suggest a novel mechanism for the regulation of mRNA transcription and capping in dsRNA viruses.

A comparison in yeast and human cells reveals a remarkable variability in the properties of RNP granules and highlights a key role for protein disaggregation machines in regulating RNP granule assembly.

Two newly identified assembly factors for the ribosome-associated iron-sulfur protein Rli1 reveal a general mechanism for how the cytosolic iron-sulfur protein assembly (CIA) machinery recruits apoproteins.

Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.

Specific elements of the canonical nucleosome are recognized by the multi-component SWR1 chromatin remodeler for ATP-dependent replacement of H2A-H2B dimers with H2A.Z-H2B.

Cells use two interdigitated biosynthetic pathways that can be regulated independently to produce diverse bioactive sterols.

Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.