Browse our latest Biochemistry and Chemical Biology articles

ESAT-6, a virulence factor of Mycobacterium tuberculosis, dimerizes at neutral pH and transitions to oligomers under acidic pH similar to that of lysosome, helping the bacterium evade host defense mechanisms.

Stramenopiles are unusual, because the pay-off phase of glycolysis occurs in mitochondria rather than the cytosol and the identified mitochondrial carrier links the two parts by transporting glycolytic intermediates.

A comprehensive analysis questioned the prevailing views of Src-mediated hPANX1 phosphorylation at Tyr199 and Tyr309.

During hibernation, animals remodel the structure of their relaxed muscle via a protein called myosin and this enables vast temperature changes.

Parallel chemical and physiological profiling of conspecific chemosensory communication in mice identifies both common and unique strategies for vomeronasal signaling of sex and strain.

Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.

A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.

Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.

High-affinity nanobodies targeting the SARS-CoV-2 spike protein demonstrate sustained effectiveness against current and emerging variants, offering a promising avenue for treatment.