Improved chemical, molecular biology, and computational approaches establish an optimized method for accurate and precise quantification of tRNA expression, modifications, and aminoacylation.
Katarzyna Marta Zoltowska, Utpal Das ... Lucía Chávez-Gutiérrez
A novel Aβ-driven inhibitory mechanism on γ-secretases, which leads to substrate accumulation and reduced release of products, contributes to neurotoxicity by impairing γ-secretase signaling and might operate in Alzheimer’s disease.
Hsp47 positively regulates the functional surface expression of endogenous GABAA receptors and plays a critical and general role in the maturation of Cys-loop neuroreceptors.
Richard Sejour, Janet Leatherwood ... Bruce Futcher
The 5' ends of genes are slightly enriched for rare codons largely because the ends turnover in evolution and gather rare codons, and these rare codons do not improve translation.
